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Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity

文献类型：期刊论文

作者Li, Qing2; Sun, Xueqi2,3; Gu, Guodong1; Guo, Zhanyong2
刊名MARINE DRUGS
出版日期2018-04-01
卷号16期号:4页码:13
关键词chitosan derivatives 1,2,3-triazolium free radical-scavenging activity
ISSN号1660-3397
DOI10.3390/md16040107
通讯作者Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要Chitosan is an abundant and renewable polysaccharide, which exhibits attractive bioactivities and natural properties. Improvement such as chemical modification of chitosan is often performed for its potential of providing high bioactivity and good water solubility. A new class of chitosan derivatives possessing 1,2,3-triazolium charged units by associating "click reaction" with efficient 1,2,3-triazole quaternization were designed and synthesized. Their free radical-scavenging activity against three free radicals was tested. The inhibitory property and water solubility of the synthesized chitosan derivatives exhibited a remarkable improvement over chitosan. It is hypothesized that triazole or triazolium groups enable the synthesized chitosan to possess obviously better radical-scavenging activity. Moreover, the scavenging activity against superoxide radical of chitosan derivatives with triazolium (IC50 < 0.01 mg mL(-1)) was more efficient than that of derivatives with triazole and Vitamin C. In the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl radical-scavenging assay, the same pattern were observed, which should be related to the triazolium grafted at the periphery of molecular chains.
资助项目National Natural Science Foundation of China[41576156] ; Natural Science Foundation of Shandong Province of China[ZR2017BD015] ; Yantai Science and Technology Development Plan[2015ZH078] ; Technology Research Funds Projects of Ocean[2015418022-3]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000431068000009
出版者MDPI
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Shandong Province of China ; Yantai Science and Technology Development Plan ; Technology Research Funds Projects of Ocean
源URL[http://ir.imr.ac.cn/handle/321006/127932]  
专题金属研究所_中国科学院金属研究所
通讯作者Guo, Zhanyong
作者单位1.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China
3.Grad Sch Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式
GB/T 7714		 Li, Qing,Sun, Xueqi,Gu, Guodong,et al. Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity[J]. MARINE DRUGS,2018,16(4):13.
APA Li, Qing,Sun, Xueqi,Gu, Guodong,&Guo, Zhanyong.(2018).Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity.MARINE DRUGS,16(4),13.
MLA Li, Qing,et al."Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity".MARINE DRUGS 16.4(2018):13.

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来源：金属研究所

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