Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system
文献类型：期刊论文
| 作者 | Lv, Xiaojie1,2; Zhang, Wenchang2; Liu, Yunen3; Zhao, Yan2; Zhang, Jinsong2; Hou, Mingxiao3 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2018-10-15 |
| 卷号 | 198页码:86-93 |
| 关键词 | Polyelectrolyte complex hydrogels pH-sensitive Superabsorbent Electrostatic Interactions Oral drug delivery |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2018.06.058 |
| 通讯作者 | Zhao, Yan(yanzhao@imr.ac.cn) ; Zhang, Jinsong(jshzhang@imr.ac.cn) |
| 英文摘要 | Polyelectrolyte complex (PECs) hydrogels with high hygroscopicity modulation ability were successfully prepared based on carboxymethyl chitosan (CMCS)/alginate. The swelling ratio of the hydrogels could be tuned from 1 to 450 simply by changing the weight ratio of CMCS to alginate, and superabsorbent hydrogels were obtained when the weight ratio of CMCS to alginate was below 1/1. Also, the swelling kinetics and water diffusion mechanism in the hydrogels were discussed. In vitro cytotoxicity results indicated that hydrogels had excellent cytocompatibility. The swelling ratio of the hydrogel as well as its BSA releasing profile was notably pH dependent. Compared with the values at pH 1.2, the swelling ratio of hydrogels (CMCS/alginate weight ratio of 1/2) at pH 7.4 was about 34 times higher, and the amount of BSA released at pH 7.4 was also significantly higher. The as-prepared CMCS/alginate PECs hydrogels hold great potential for oral delivery of protein drugs through the intestinal tract. |
| 资助项目 | National Key Research and Development Plan[2016YFB0301502] ; National Natural Science Foundation of China[U1608255] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000440785200011 |
| 出版者 | ELSEVIER SCI LTD |
| 资助机构 | National Key Research and Development Plan ; National Natural Science Foundation of China |
| 源URL | [http://ir.imr.ac.cn/handle/321006/129002]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Zhao, Yan; Zhang, Jinsong |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China 3.Gen Hosp Shenyang Mil Command, Dept Emergency Med, Shenyang 110016, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Xiaojie,Zhang, Wenchang,Liu, Yunen,et al. Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system[J]. CARBOHYDRATE POLYMERS,2018,198:86-93. |
| APA | Lv, Xiaojie,Zhang, Wenchang,Liu, Yunen,Zhao, Yan,Zhang, Jinsong,&Hou, Mingxiao.(2018).Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system.CARBOHYDRATE POLYMERS,198,86-93. |
| MLA | Lv, Xiaojie,et al."Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system".CARBOHYDRATE POLYMERS 198(2018):86-93. |
入库方式： OAI收割
来源：金属研究所
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