Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity
文献类型：期刊论文
| 作者 | Zhang, Xuejiao2; Lei, Lei1,2; Zhang, Haiyan3; Zhang, Siyu2,5; Xing, Weiwei4; Wang, Jin4; Li, Haibo3,5; Zhao, Qing2; Xing, Baoshan5 |
| 刊名 | ENVIRONMENTAL POLLUTION
 |
| 出版日期 | 2018-10-01 |
| 卷号 | 241页码:701-709 |
| 关键词 | Polymeric nanomicelles Organic pollutants Partitioning behavior Combined cytotoxicity Biointerfacial behavior |
| ISSN号 | 0269-7491 |
| DOI | 10.1016/j.envpol.2018.06.010 |
| 通讯作者 | Zhao, Qing(zhaoqing@iae.ac.cn) |
| 英文摘要 | Attention has been paid to the environmental distribution and fate of nanomedicines. However, their effects on the toxicity of environmental pollutants are lack of knowledge. In this study, the negatively charged poly (ethylene glycol)-b-poly (L-lactide-co-glycolide) (mPEG-PLA) and positively charged polyethyleneimine-palmitate (PEI-PA) nanomicelles were synthesized and served as model drug carriers to study the interaction and combined toxicity with dichlorodiphenyltrichloroethane (DDT). DDT exerted limited effect on the biointerfacial behavior of mPEG-PLA nanomicelles, whereas it significantly mitigated the attachment of PEI-PA nanomicelles on the model cell membrane as monitored by quartz crystal microbalance with dissipation (QCM-D). The cytotoxicity of DDT towards NIH 3T3 cells was greatly decreased by either co-treatment or pre-treatment with the nanomicelles according to the results of real-time cell analysis (RICA). The cell viability of NIH 3T3 exposed to DDT was increased up to 90% by the co-treatment with mPEG-PLA nanomicelles. Three possible reasons were proposed: (1) decreased amount of free DDT in the cell culture medium due to the partitioning of DDT into nanomicelles; (2) mitigated cellular uptake of nanomicelle-DDT complexes due to the complex agglomeration or electrostatic repulsion between complexes and cell membrane; (3) detoxification effect in the lysosome upon endocytosis of nanomicelle-DDT complexes. (C) 2018 Elsevier Ltd. All rights reserved. |
| 资助项目 | National Natural Science Foundation of China[41603120] ; National Natural Science Foundation of China[41703107] ; National Natural Science Foundation of China[21671115] ; National Key Research and Development Program of China[2016YFD0800300] ; Youth Innovation Promotion Association CAS ; Key Laboratory of Industrial Ecology and Environmental Engineering (MOE) ; Hundreds Talents Program of Chinese Academy of Sciences |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:000440390800075 |
| 出版者 | ELSEVIER SCI LTD |
| 资助机构 | National Natural Science Foundation of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association CAS ; Key Laboratory of Industrial Ecology and Environmental Engineering (MOE) ; Hundreds Talents Program of Chinese Academy of Sciences |
| 源URL | [http://ir.imr.ac.cn/handle/321006/129049]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Zhao, Qing |
| 作者单位 | 1.Univ Chinese Acad Sci, Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Appl Ecol, Key Lab Pollut Ecol & Environm Engn, Shenyang, Liaoning, Peoples R China 3.Northeastern Univ, Sch Resources & Civil Engn, Shenyang 110004, Liaoning, Peoples R China 4.Liaoning Beifang Environm Technol Co LTD, Shenyang 110161, Liaoning, Peoples R China 5.Univ Massachusetts, Stockbridge Sch Agr, Amherst, MA 01003 USA |
| 推荐引用方式 GB/T 7714 | Zhang, Xuejiao,Lei, Lei,Zhang, Haiyan,et al. Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity[J]. ENVIRONMENTAL POLLUTION,2018,241:701-709. |
| APA | Zhang, Xuejiao.,Lei, Lei.,Zhang, Haiyan.,Zhang, Siyu.,Xing, Weiwei.,...&Xing, Baoshan.(2018).Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity.ENVIRONMENTAL POLLUTION,241,701-709. |
| MLA | Zhang, Xuejiao,et al."Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity".ENVIRONMENTAL POLLUTION 241(2018):701-709. |
入库方式： OAI收割
来源：金属研究所
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