Study of engineered low-modulus Mg/PLLA composites as potential orthopaedic implants: An in vitro and in vivo study
文献类型：期刊论文
| 作者 | Yu, Xiaobing1,2,3; Huang, Wei2; Zhao, Dewei2,3; Yang, Ke1; Tan, Lili1; Zhang, Xiuzhi2; Li, Junlei2; Zhang, Meng2; Zhang, Shuo2; Liu, Tao2 |
| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
 |
| 出版日期 | 2019-02-01 |
| 卷号 | 174页码:280-290 |
| ISSN号 | 0927-7765 |
| 关键词 | Poly-lactic acid Magnesium Mg/PLLA composite Bone formation Osteogenesis differentiation |
| DOI | 10.1016/j.colsurfb.2018.10.054 |
| 通讯作者 | Zhao, Dewei(zhaodewei2016@163.com) ; Yang, Ke() |
| 英文摘要 | Low molecular weight poly-lactic acid (PLLA) is a polymer matrix of orthopaedic implants. The PLLA matrix incorporating bioactive magnesium ion (Mg2+) enhances bone regeneration. But the optimal ratio of Mg2+ to PLLA matrix has not been well reported and is worthy of study. We synthesized silane-coated Mg/PLLA composites containing 1%, 2%, 3%, 4% and 5% Mg micro-particles. The mechanical properties, in vitro cytocompatibility, cell viability and osteogenesis differentiation and in vivo performance of silane-coated Mg/PLLA composites were evaluated. These results showed that the bending and tensile strength of PLLA matrix was reduced by incorporation of Mg micro-particles. Mg/PLLA composites with higher Mg micro-particles ratio showed higher Mg2+ leaching rate and pH value in immersion solutions. MC3T3-E1 pre-osteoblasts incubated with Mg/PLLA composites containing higher ratio of Mg micro-particles showed higher cytocompatibility, cell viability, osteogenesis differentiation and migration. In vitro cellular responses showed that MC3T3-E1 preosteoblasts had the highest cell viability at 50 ppm Mg2+. In vivo animal studies showed there was no change in serum Mg 2+ concentration after implanting Mg/PLLA composites comparing with control and the implants of silane-coated Mg/PLLA composites accelerated bone formation. In summary, our study revealed the feasibility of silane-coated Mg/PLLA composites as orthopaedic implants. Silane-coated Mg/PLLA composites with Mg micro-particles ratio of 3% similar to 5% were optimal substitutes for bone regeneration. |
| 资助项目 | National Natural Science Foundation of China[81672139] |
| WOS研究方向 | Biophysics ; Chemistry ; Materials Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000459840800033 |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.imr.ac.cn/handle/321006/132124]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Zhao, Dewei; Yang, Ke |
| 作者单位 | 1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China 2.Dalian Univ, Zhongshan Hosp, Dept Orthopaed, Dalian 116001, Peoples R China 3.Dalian Univ, Zhongshan Hosp, Postdoctoral Workstn, Dalian 116001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Xiaobing,Huang, Wei,Zhao, Dewei,et al. Study of engineered low-modulus Mg/PLLA composites as potential orthopaedic implants: An in vitro and in vivo study[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2019,174:280-290. |
| APA | Yu, Xiaobing.,Huang, Wei.,Zhao, Dewei.,Yang, Ke.,Tan, Lili.,...&Yuan, Yashuai.(2019).Study of engineered low-modulus Mg/PLLA composites as potential orthopaedic implants: An in vitro and in vivo study.COLLOIDS AND SURFACES B-BIOINTERFACES,174,280-290. |
| MLA | Yu, Xiaobing,et al."Study of engineered low-modulus Mg/PLLA composites as potential orthopaedic implants: An in vitro and in vivo study".COLLOIDS AND SURFACES B-BIOINTERFACES 174(2019):280-290. |
入库方式： OAI收割
来源：金属研究所
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