Surface degradation-enabled osseointegrative, angiogenic and antiinfective properties of magnesium-modified acrylic bone cement
文献类型：期刊论文
| 作者 | Lin, Xiao1,6; Ge, Jun1,6; Wei, Donglei1,6; Liu, Chun1,6; Tan, Lili5; Yang, Huilin1,3,6; Yang, Ke5; Zhou, Huan3,4; Li, Bin1,3,6; Luo, Zong-Ping1,3,6 |
| 刊名 | JOURNAL OF ORTHOPAEDIC TRANSLATION
 |
| 出版日期 | 2019-04-01 |
| 卷号 | 17页码:121-132 |
| 关键词 | Antiinfection Bone cement Kyphoplasty Magnesium Osseointegration |
| ISSN号 | 2214-031X |
| DOI | 10.1016/j.jot.2019.04.007 |
| 通讯作者 | Li, Bin(binli@suda.edu.cn) ; Luo, Zong-Ping(zongping_luo@yahoo.com) ; Yang, Lei(ylei@hebut.edu.cn) |
| 英文摘要 | Objective: This work focuses on tackling the inadequate bone/implant interface strength of acrylic bone cements, which is a formidable problem diminishing their clinical performance, especially in percutaneous kyphoplasty surgery. Methods: A new strategy of incorporating magnesium particles into clinically used poly(methylmethacrylate) (PMMA) bone cement to prepare a surface-degradable bone cement (SdBC) is proposed and validated both in vitro and in vivo. Results: This surface degradation characteristic enables osseointegrative, angiogenic and anti-infective properties. SdBC showed fast surface degradation and formed porous surfaces as designed, while the desirable high compressive strengths (>= 70 MPa) of the cement were preserved. Besides, the SdBC with proper Mg content promoted osteoblast adhesion, spreading, proliferation and endothelial cell angiogenesis capacity compared with PMMA. Also, SdBC demonstrated clear inhibitory effect on Staphylococcus aureus and Escherichia coli. In vivo evaluation on SdBC by the rat femur defect model showed that the bone/implant interface strength was significantly enhanced in SdBC (push-out force of 11.8 +/- 1.5 N for SdBC vs 7.0 +/- 2.3N for PMMA), suggesting significantly improved osseointegration and bone growth induced by the surface degradation of the cement. The injectability, setting times and compressive strengths of SdBC with proper content of Mg particles (2.8 wt% and 5.4 wt%) were comparable with those of the clinical acrylic bone cement, while the heat release during polymerization was reduced (maximum temperature 78 +/- 1 degrees C for PMMA vs 73.3 +/- 1.5 degrees C for SdBC). Conclusions: This work validates a new concept of designing bioactive bone/implant interface in PMMA bone cement. And this surface-degradable bone cement possesses great potential for minimally invasive orthopaedic surgeries such as percutaneous kyphoplasty. The translational potential of this article: This work reports PMMA/Mg surface-degradable acrylic bone cements that possess enhanced osseointegrative, angiogenic and antiinfective properties that are lacking in the clinically used acrylic bone cements. This new kind of bone cements could improve the treatment outcome of many orthopaedic surgeries such as percutaneous kyphoplasty and arthroplasty. (C) 2019 The Authors. Published by Elsevier (Singapore) Pte Ltd on behalf of Chinese Speaking Orthopaedic Society. |
| 资助项目 | National Natural Science Foundation of China[81501858] ; National Natural Science Foundation of China[81622032] ; National Natural Science Foundation of China[51672184] ; Jiangsu Innovation and Entrepreneurship Program ; National Basic Research Program of China [973 Program][2014CB748600] ; Priority Academic Program Development of Jiangsu High Education Institutions (PAPD) |
| WOS研究方向 | Orthopedics |
| 语种 | 英语 |
| WOS记录号 | WOS:000470125300013 |
| 出版者 | ELSEVIER SCIENCE BV |
| 资助机构 | National Natural Science Foundation of China ; Jiangsu Innovation and Entrepreneurship Program ; National Basic Research Program of China [973 Program] ; Priority Academic Program Development of Jiangsu High Education Institutions (PAPD) |
| 源URL | [http://ir.imr.ac.cn/handle/321006/133850]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Li, Bin; Luo, Zong-Ping; Yang, Lei |
| 作者单位 | 1.Soochow Univ, Affiliated Hosp 1, Inst Orthopaed, Suzhou 215006, Peoples R China 2.Hebei Univ Technol, Sch Mat Sci & Engn, Ctr Hlth Sci & Engn, Tianjin 300310, Peoples R China 3.IRCTO, Suzhou 215006, Peoples R China 4.Jiangsu Univ Technol, Sch Mech Engn, Changzhou 213001, Peoples R China 5.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China 6.Soochow Univ, Affiliated Hosp 1, Dept Orthopaed, Suzhou 215006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Xiao,Ge, Jun,Wei, Donglei,et al. Surface degradation-enabled osseointegrative, angiogenic and antiinfective properties of magnesium-modified acrylic bone cement[J]. JOURNAL OF ORTHOPAEDIC TRANSLATION,2019,17:121-132. |
| APA | Lin, Xiao.,Ge, Jun.,Wei, Donglei.,Liu, Chun.,Tan, Lili.,...&Yang, Lei.(2019).Surface degradation-enabled osseointegrative, angiogenic and antiinfective properties of magnesium-modified acrylic bone cement.JOURNAL OF ORTHOPAEDIC TRANSLATION,17,121-132. |
| MLA | Lin, Xiao,et al."Surface degradation-enabled osseointegrative, angiogenic and antiinfective properties of magnesium-modified acrylic bone cement".JOURNAL OF ORTHOPAEDIC TRANSLATION 17(2019):121-132. |
入库方式： OAI收割
来源：金属研究所
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