In vitro and in vivo characterization of novel calcium phosphate and magnesium (CaP-Mg) bilayer coated titanium for implantation
文献类型：期刊论文
| 作者 | Chen, Lanyue2,4; Yan, Xudong1,3; Tan, Lili1; Zheng, Bowen2; Muhammed, Fenik Kaml2; Yang, Ke1; Liu, Yi2 |
| 刊名 | SURFACE & COATINGS TECHNOLOGY
 |
| 出版日期 | 2019-09-25 |
| 卷号 | 374页码:784-796 |
| 关键词 | Bilayer coating Degradation behavior Antibacterial ability Osteoconductivity |
| ISSN号 | 0257-8972 |
| DOI | 10.1016/j.surfcoat.2019.06.023 |
| 通讯作者 | Yang, Ke(kyang@imr.ac.cn) ; Liu, Yi(liuyi@cmu.edu.cn) |
| 英文摘要 | A novel bio-functional calcium phosphate and magnesium (CaP-Mg) bilayer coating on titanium (Ti) was fabricated and characterized in vitro and in vivo. The bilayer coating was fabricated by biomimetic method and physical vapor deposition (PVD). The intermediate calcium phosphate (CaP) layer was mainly composed of octacalcium phosphate (OCP) and hydroxyapatite (HA). Compared to the single magnesium (Mg) coating, Mg layer on bilayer coating was thicker, coarser and porous. Immersion test and electrochemical test showed that the intermediate CaP layer could not decrease the degradation rate, however, inhibit detachment of Mg. The Mg coating delaminated from the single Mg coated sample following immersion for 1 day, while no obvious evidence of detachment was observed for the bilayer even after immersion for 14 days. In vitro antibacterial assays proved that the CaP-Mg coating strongly reduced the viability of Staphylococcus aureus and performed an about 90% antibacterial efficacy after 3 h incubation due to high alkalinity produced by the degradation of Mg. The bare Ti bar and coated Ti bar implants were implanted into New Zealand white rabbit lower jaws for 4 and 12 weeks, respectively. Cone beam computed tomography (CBCT), and Masson and hematoxyline-eosin (HE) staining showed CaP-Mg coated Ti bar promoted superior osteointegration after 4 and 12 weeks implantations. |
| 资助项目 | Liaoning Province Nature Science fund project[20180550420] |
| WOS研究方向 | Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000486360000078 |
| 出版者 | ELSEVIER SCIENCE SA |
| 资助机构 | Liaoning Province Nature Science fund project |
| 源URL | [http://ir.imr.ac.cn/handle/321006/135572]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Yang, Ke; Liu, Yi |
| 作者单位 | 1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China 2.China Med Univ, Sch Stomatol, Dept Orthodont, Shenyang 110001, Liaoning, Peoples R China 3.Cent S Univ, Shoot Mat Sci & Engn, Changsha 410083, Hunan, Peoples R China 4.Guilin Med Univ, Sch Stomatol, Dept Orthodont, Guilin 541001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Lanyue,Yan, Xudong,Tan, Lili,et al. In vitro and in vivo characterization of novel calcium phosphate and magnesium (CaP-Mg) bilayer coated titanium for implantation[J]. SURFACE & COATINGS TECHNOLOGY,2019,374:784-796. |
| APA | Chen, Lanyue.,Yan, Xudong.,Tan, Lili.,Zheng, Bowen.,Muhammed, Fenik Kaml.,...&Liu, Yi.(2019).In vitro and in vivo characterization of novel calcium phosphate and magnesium (CaP-Mg) bilayer coated titanium for implantation.SURFACE & COATINGS TECHNOLOGY,374,784-796. |
| MLA | Chen, Lanyue,et al."In vitro and in vivo characterization of novel calcium phosphate and magnesium (CaP-Mg) bilayer coated titanium for implantation".SURFACE & COATINGS TECHNOLOGY 374(2019):784-796. |
入库方式： OAI收割
来源：金属研究所
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