Effect of biodegradable magnesium-copper coatings on bone integration based on the porous structures in a rabbit model
文献类型：期刊论文
| 作者 | Ding, Yurun3; Du, Zhe1; Zhu, Zhonglin4; Yu, Xiaoming2; Wang, You3 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:44页码:25127-25132 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c8ra03157f |
| 通讯作者 | Wang, You(drwangyou@163.com) |
| 英文摘要 | Biodegradable magnesium (Mg)-copper (Cu) coatings are promising in orthopedic implants to enhance osteogenesis. The present study aimed to compare the osteogenic effect of Mg-Cu coating and non-coating implants using a rabbit model. Mg/Mg-Cu coating of porous Ti6Al4V alloys was performed by the arc ion plating method. Five porous implants (smooth, porous, Mg coated, Mg-0.1Cu coated, and Mg-0.7Cu coated) were implanted into the distal femurs of the rabbits. The rabbits were sacrificed after one and two months, respectively, and the distal femurs with the implants were analyzed via micro-computed tomography (CT), double fluorescent labeling, and hard tissue biopsy to evaluate their osteogenic effect. During the two months of observation, the Mg/Mg-Cu coatings exhibited no advantages when compared with the bare porous structures in terms of bone integration; however, the porous structures were more conducive for bone ingrowth than the smooth implants. The osteogenic application of Mg-Cu coated orthopedic implants is worth further investigation. Furthermore, due to its long-term antibacterial ability, the biodegradable Mg-Cu coatings are promising in orthopedic applications. |
| 资助项目 | National Key R&D Program of China[2016YFC1101802] ; National Key R&D Program of China[2016YFC1101804] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000438939300050 |
| 资助机构 | National Key R&D Program of China |
| 源URL | [http://ir.imr.ac.cn/handle/321006/135869]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Wang, You |
| 作者单位 | 1.Peking Univ, Peoples Hosp, Trauma & Emergency Ctr, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang, Liaoning, Peoples R China 3.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Bone & Joint Surg, 145 Middle Shandong Rd, Shanghai 200001, Peoples R China 4.Jiangsu OKANI Med Technol Co Ltd, Suzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Yurun,Du, Zhe,Zhu, Zhonglin,et al. Effect of biodegradable magnesium-copper coatings on bone integration based on the porous structures in a rabbit model[J]. RSC ADVANCES,2018,8(44):25127-25132. |
| APA | Ding, Yurun,Du, Zhe,Zhu, Zhonglin,Yu, Xiaoming,&Wang, You.(2018).Effect of biodegradable magnesium-copper coatings on bone integration based on the porous structures in a rabbit model.RSC ADVANCES,8(44),25127-25132. |
| MLA | Ding, Yurun,et al."Effect of biodegradable magnesium-copper coatings on bone integration based on the porous structures in a rabbit model".RSC ADVANCES 8.44(2018):25127-25132. |
入库方式： OAI收割
来源：金属研究所
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