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Assessment of structure integrity, corrosion behavior and microstructure change of AZ31B stent in porcine coronary arteries

文献类型：期刊论文

作者Chen, Shanshan1; Zhang, Bin2; Zhang, Bingchun1; Lin, Hao1; Yang, Hui1; Zheng, Feng1; Chen, Ming2; Yang, Ke1
刊名JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
出版日期2020-02-15
卷号39页码:39-47
ISSN号1005-0302
关键词AZ31B Coronary stent Structural integrity Degradation Microstructure
DOI10.1016/j.jmst.2018.12.017
通讯作者Chen, Ming(cm6141@sina.com) ; Yang, Ke(keyang@imr.ac.cn)
英文摘要Magnesium alloy coronary stent becomes a hot research topic due to its biodegradable character for avoiding late thrombosis and late restenosis. However, fracture of Mg alloy stent was a common issue after implantation. In this study, 18 drug-eluting biodegradable AZ31B stents were implanted into porcine coronary arteries to assess its structural integrity, corrosion behavior and microstructure change in vivo. The coronary artery tissue responses to AZ31B stent implantation were detected by quantitative coronary angiography and optical coherence tomography at the set time periods. In addition, further analyses were focused on the stent structure integrity, corrosion behaviors and the microstructure change of Mg alloy stents after implantation. A large number of fractures on stent struts were observed by high-resolution transmission X-ray tomography clearly. Moreover, degradation products, twins and grain refinement that appeared in Mg alloy stent matrix after implantation were also observed during the study. Inferred from this study, it is shown that the loss of AZ31B stent structural integrity may be the result of stress concentration, degradation and microstructure change. (C) 2019 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
资助项目National Key Research and Development Program of China[2016YFC1102404]
WOS研究方向Materials Science ; Metallurgy & Metallurgical Engineering
语种英语
出版者JOURNAL MATER SCI TECHNOL
WOS记录号WOS:000510492000006
资助机构National Key Research and Development Program of China
源URL[http://ir.imr.ac.cn/handle/321006/137148]  
专题金属研究所_中国科学院金属研究所
通讯作者Chen, Ming; Yang, Ke
作者单位1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
2.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Shanshan,Zhang, Bin,Zhang, Bingchun,et al. Assessment of structure integrity, corrosion behavior and microstructure change of AZ31B stent in porcine coronary arteries[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2020,39:39-47.
APA Chen, Shanshan.,Zhang, Bin.,Zhang, Bingchun.,Lin, Hao.,Yang, Hui.,...&Yang, Ke.(2020).Assessment of structure integrity, corrosion behavior and microstructure change of AZ31B stent in porcine coronary arteries.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,39,39-47.
MLA Chen, Shanshan,et al."Assessment of structure integrity, corrosion behavior and microstructure change of AZ31B stent in porcine coronary arteries".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 39(2020):39-47.

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来源：金属研究所

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