Mechanical, Biological, and Antibacterial Characteristics of Plasma-Sprayed (Sr,Zn) Substituted Hydroxyapatite Coating
文献类型：期刊论文
| 作者 | Ullah, Ihsan1,2; Siddiqui, Muhammad Ali1,2; Liu, Hui1,2; Kolawole, Sharafadeen Kunle1,2; Zhang, Ji1; Zhang, Shuyuan1; Ren, Ling1; Yang, Ke1 |
| 刊名 | ACS BIOMATERIALS SCIENCE & ENGINEERING
 |
| 出版日期 | 2020-03-01 |
| 卷号 | 6期号:3页码:1355-1366 |
| 关键词 | HA coating plasma spray heat treatment antibacterial properties biocompatibility |
| ISSN号 | 2373-9878 |
| DOI | 10.1021/acsbiomaterials.9b01396 |
| 通讯作者 | Ren, Ling(lren@imr.ac.cn) |
| 英文摘要 | Implant-related infections are a major concern in total joint prostheses, occurring up to 3% in operations. In this work, 5% Zn2+ was added in I-TA to offset bacterial activity and 5% Sr2+ was also incorporated as a binary dopant to reduce the cytotoxic effect of Zn2+. The nanosized HA powder was synthesized by the hydrothermal method and then heat-treated at 600 degrees C for 4 h. The heat-treated powder was plasma-sprayed on a titanium alloy Ti-6Al-4V substrate. The addition of the dopant did not significantly influence the physical and mechanical properties of the coating. However, the cytocompatibility, antimicrobial, and contact-angle properties statistically enhanced. Moreover, the (Sr,Zn)-HA coating was post-heat treated at 500 and 600 degrees C for 3 h. X-ray diffraction confirmed that after heat treatment phase purity and crystallinity increased and residual stress decreased. Mechanical stability was evaluated by adhesive bond strength, and the results showed that after heat-treatment bonding strength increased from 26.81 +/- 2.93 to 29.84 +/- 3.62 and 34.66 +/- 2.57 MPa, at 500 and 600 degrees C, respectively. Similar to the mechanical property, antibacterial activities and biological functions are also significantly improved. More interestingly, it was also observed that the Zn2+ ions released from the coating depend on Ca2+, P, and Sr2+ ions while Ca2+, P, and Sr2+ ions relied on heat treatment temperatures. However, (Sr,Zn)-HA coating at 600 degrees C demonstrates cytotoxic effects on MC3T3-E1 cells, characterized by poor cellular morphology on the coating surface and ultimately, cell death. The doping of Sr2+ with Zn2+, therefore, can offset the cytotoxic effects and enhanced biological performance. All of the outcomes of this study signify that (Sr,Zn)-HA coating heat-treated at 500 degrees C showed not only excellent mechanical and biological performance but also enhanced the antibacterial properties. |
| 资助项目 | National Key Research and Development Program of China[2018YFC1106601] ; National Key Research and Development Program of China[2016YFC1100600] ; National Natural Science Foundation[51631009] ; Youth Innovation Promotion Association, CAS[2014168] ; Promoting Liaoning Province Talents Program-Top Young Talents[XLYC1807069] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000519150300005 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Key Research and Development Program of China ; National Natural Science Foundation ; Youth Innovation Promotion Association, CAS ; Promoting Liaoning Province Talents Program-Top Young Talents |
| 源URL | [http://ir.imr.ac.cn/handle/321006/137833]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Ren, Ling |
| 作者单位 | 1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ullah, Ihsan,Siddiqui, Muhammad Ali,Liu, Hui,et al. Mechanical, Biological, and Antibacterial Characteristics of Plasma-Sprayed (Sr,Zn) Substituted Hydroxyapatite Coating[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2020,6(3):1355-1366. |
| APA | Ullah, Ihsan.,Siddiqui, Muhammad Ali.,Liu, Hui.,Kolawole, Sharafadeen Kunle.,Zhang, Ji.,...&Yang, Ke.(2020).Mechanical, Biological, and Antibacterial Characteristics of Plasma-Sprayed (Sr,Zn) Substituted Hydroxyapatite Coating.ACS BIOMATERIALS SCIENCE & ENGINEERING,6(3),1355-1366. |
| MLA | Ullah, Ihsan,et al."Mechanical, Biological, and Antibacterial Characteristics of Plasma-Sprayed (Sr,Zn) Substituted Hydroxyapatite Coating".ACS BIOMATERIALS SCIENCE & ENGINEERING 6.3(2020):1355-1366. |
入库方式： OAI收割
来源：金属研究所
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