Mechanical properties, biodegradability and cytocompatibility of biodegradable Mg-Zn-Zr-Nd/Y alloys
文献类型：期刊论文
| 作者 | Jin, Shi2,3; Zhang, Dan2,3; Lu, Xiaopeng1; Zhang, Yang2,3; Tan, Lili4; Liu, Ying5; Wang, Qiang2,3 |
| 刊名 | JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2020-06-15 |
| 卷号 | 47页码:190-201 |
| 关键词 | Magnesium Mg-Zn-Zr-Nd alloy Mg-Zn-Zr-Y alloy Biodegradable implant Biocompatibility |
| ISSN号 | 1005-0302 |
| DOI | 10.1016/j.jmst.2020.02.017 |
| 通讯作者 | Zhang, Yang(kp3666@126.com) ; Wang, Qiang(mfqwang@163.com) |
| 英文摘要 | Biodegradable magnesium alloys have been turned out to be a promising candidate for orthopedic applications. In this study, the mechanical properties, degradation behavior and cytocompatibility of Mg-Zn-Zr-Nd and Mg-Zn-Zr-Y alloys were studied in comparison with pure Mg. Mechanical tests showed that the strength and ductility of Mg-Zn-Zr-Nd and Mg-Zn-Zr-Y alloys were excellent. The corrosion resistance analyzed by electrochemical test and immersion test in alpha modified eagle (alpha-MEM) medium with 10% fetal bovine serum (FBS) revealed the degradation of Mg-Zn-Zr-Nd and Mg-Zn-Zr-Y alloys were faster than pure Mg at an early stage but slowed down after long time immersion. The metal ion concentrations were consistent with the corrosion rate. Mg-Zn-Zr-Nd alloy shows better mechanical properties than pure Mg and better corrosion resistance than Mg-Zn-Zr-Y alloy. The direct and indirect in vitro tests with MC3T3-E1 cells demonstrate that Mg-Zn-Zr-Nd shows the best cytocompatibility and osteogenesis. The results suggest that Mg-Zn-Zr-Nd alloy shows an ideal combination of mechanical, corrosive and biological properties. In summary, these results implying the Mg-Zn-Zr-Nd alloy has great potential to benefit the future development of orthopedic applications. (C) 2020 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology. |
| 资助项目 | National NaturalScience Foundation of China[U1737102] ; Young Elite Scientists Sponsorship Program by China Association for Science andTechnology[2017QNRC001] ; Shenyang Key R&D and Technology Transfer Program[Z18-0-027] ; Key Programof China on Biomedical Materials Research and Tissue and OrganReplacement[2016YFC1101804] ; Key Programof China on Biomedical Materials Research and Tissue and OrganReplacement[2016YFC1100604] |
| WOS研究方向 | Materials Science ; Metallurgy & Metallurgical Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:000526956900020 |
| 出版者 | JOURNAL MATER SCI TECHNOL |
| 资助机构 | National NaturalScience Foundation of China ; Young Elite Scientists Sponsorship Program by China Association for Science andTechnology ; Shenyang Key R&D and Technology Transfer Program ; Key Programof China on Biomedical Materials Research and Tissue and OrganReplacement |
| 源URL | [http://ir.imr.ac.cn/handle/321006/138412]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Zhang, Yang; Wang, Qiang |
| 作者单位 | 1.Northeastern Univ, Shenyang Natl Lab Mat Sci, Shenyang 110819, Peoples R China 2.China Med Univ, Sch & Hosp Stomatol, Shenyang 110001, Peoples R China 3.Liaoning Prov Key Lab Oral Dis, Shenyang 110001, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 5.Jiamusi Univ, Sch Stomatol, Jiamusi 154007, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Shi,Zhang, Dan,Lu, Xiaopeng,et al. Mechanical properties, biodegradability and cytocompatibility of biodegradable Mg-Zn-Zr-Nd/Y alloys[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2020,47:190-201. |
| APA | Jin, Shi.,Zhang, Dan.,Lu, Xiaopeng.,Zhang, Yang.,Tan, Lili.,...&Wang, Qiang.(2020).Mechanical properties, biodegradability and cytocompatibility of biodegradable Mg-Zn-Zr-Nd/Y alloys.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,47,190-201. |
| MLA | Jin, Shi,et al."Mechanical properties, biodegradability and cytocompatibility of biodegradable Mg-Zn-Zr-Nd/Y alloys".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 47(2020):190-201. |
入库方式： OAI收割
来源：金属研究所
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