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Novel injectable and self-setting composite materials for bone defect repair

文献类型：期刊论文

作者Xu, Qian1,3; Liang, Jiulong4; Xue, Haipeng4; Liu, Yun'en4; Cao, Lei1,2; Li, Xiaowu3; Tian, Jing4; Zhang, Xing1,2
刊名SCIENCE CHINA-MATERIALS
出版日期2020-05-01
卷号63期号:5页码:876-887
ISSN号2095-8226
关键词nanoparticles magnesium substitution injectable materials self-setting bone defect repair
DOI10.1007/s40843-019-1233-7
通讯作者Li, Xiaowu(xwli@mail.neu.edu.cn) ; Tian, Jing(soldier_chn@163.com) ; Zhang, Xing(xingzhang@imr.ac.cn)
英文摘要Although calcium sulfate bone cements possess favorable characteristics of excellent clinical handling and osteoconductivity, the rapid degradation and poor bioactivity limit their wide applications. This study reports a type of novel injectable and self-setting composite materials for bone defect repair. Magnesium substituted tricalcium phosphate nanoparticles (43.8 +/- 9.0 nm) and calcium sulfate hemihydrate micro-size particles (5-21 mu m) were mixed with a polyvinyl alcohol solution with optimal compositions to obtain the composite materials, which showed reasonable initial setting time (11.7-19.2 min) and suitable compressed strength (2.28-6.33 MPa). By utilizing magnesium powder as a porogen, macro-pores (>100 mu m) together with micro-pores were created in the final product after setting. In addition, MC3T3E1 cells extended well and exhibited numerous lamellipodia and long filopodia when cultured with the composite materials, indicating that they had no cytotoxicity. The in vivo results indicated that the injectable composite materials could achieve bone defect repair, when implanted in beagle femoral condyle defects for 10 months. Our results show that the new injectable composite materials are biocompatible and biodegradable, which possess great potential for bone defect repair.
资助项目Key Research Program of Frontier Sciences[QYZDY-SSW-JSC031] ; Chinese Academy of Sciences (CAS) ; Key Research and Development Program of Liaoning Province[201703031] ; Liaoning Science and Technology Project[20170540972] ; Shenyang Key R&D and Technology Transfer Program[Z17-7-023]
WOS研究方向Materials Science
语种英语
出版者SCIENCE PRESS
WOS记录号WOS:000528009400019
资助机构Key Research Program of Frontier Sciences ; Chinese Academy of Sciences (CAS) ; Key Research and Development Program of Liaoning Province ; Liaoning Science and Technology Project ; Shenyang Key R&D and Technology Transfer Program
源URL[http://ir.imr.ac.cn/handle/321006/138443]  
专题金属研究所_中国科学院金属研究所
通讯作者Li, Xiaowu; Tian, Jing; Zhang, Xing
作者单位1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China
3.Northeastern Univ, Minist Educ, Key Lab Anisotropy & Texture Mat, Sch Mat Sci & Engn,Dept Mat Phys & Chem, Shenyang 110819, Peoples R China
4.Gen Hosp Northern Theater Command, Shenyang 110016, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Qian,Liang, Jiulong,Xue, Haipeng,et al. Novel injectable and self-setting composite materials for bone defect repair[J]. SCIENCE CHINA-MATERIALS,2020,63(5):876-887.
APA Xu, Qian.,Liang, Jiulong.,Xue, Haipeng.,Liu, Yun'en.,Cao, Lei.,...&Zhang, Xing.(2020).Novel injectable and self-setting composite materials for bone defect repair.SCIENCE CHINA-MATERIALS,63(5),876-887.
MLA Xu, Qian,et al."Novel injectable and self-setting composite materials for bone defect repair".SCIENCE CHINA-MATERIALS 63.5(2020):876-887.

入库方式： OAI收割

来源：金属研究所

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