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Facile fabrication of the zoledronate-incorporated coating on magnesium alloy for orthopaedic implants

文献类型：期刊论文

作者Chen, Shanshan2; Wan, Peng3; Zhang, Bingchun2; Yang, Ke2; Li, Yuhai1
刊名JOURNAL OF ORTHOPAEDIC TRANSLATION
出版日期2020-05-01
卷号22页码:2-6
ISSN号2214-031X
关键词Biodegradable Drug loading Magnesium alloy Orthopaedic implant Zoledronate
DOI10.1016/j.jot.2019.09.007
通讯作者Wan, Peng(wanpeng@dgut.edu.cn) ; Yang, Ke(kyang@imr.ac.cn) ; Li, Yuhai(yuhai_li@qq.com)
英文摘要Background: Bisphosphonates (BPs) are known as a group of well-established drugs which are clinically used in metabolic bone disorder-related therapies. Recently increasing interests are focused on the application of BPs in the biodegradable Mg-based implants. Methods: In this study a facile method was applied to fabricate a zoledronate loaded coating on AZ31 Mg alloy in comparison with the previous construction strategies, such as Ca-P chelation with BPs. Results: The results showed that the fluoride pretreated coating could provide better corrosion resistance. Zoledronic acid (ZA) was successfully loaded on the surface of Mg alloy detected by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FTIR) analysis, and the release profile was quantified with Ultraviolet (UV) detection. Conclusion: It is considered that this construction of ZA coated Mg-based orthopedic implants could be easily and efficiently used in clinic. The translational potential of this article: Different from the traditional drug release mode, this paper used the hydrogen bond between drug molecules and drug carriers to not only realise the effective drug release in the early stage of drug release, but also meet the continuous effect of drugs in the later stage, providing a new possibility for clinical application.
资助项目open fund of characteristic training discipline of Shenyang Ligong University[0101311008502] ; Youth Innovation Promotion Association, Chinese Academy of Sciences[2019194] ; doctoral scientific research fund of Dongguan University of Technology[GC300501-082]
WOS研究方向Orthopedics
语种英语
出版者ELSEVIER
WOS记录号WOS:000536593000002
资助机构open fund of characteristic training discipline of Shenyang Ligong University ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; doctoral scientific research fund of Dongguan University of Technology
源URL[http://ir.imr.ac.cn/handle/321006/139138]  
专题金属研究所_中国科学院金属研究所
通讯作者Wan, Peng; Yang, Ke; Li, Yuhai
作者单位1.Shenyang Ligong Univ, Sch Mat, Shenyang 110168, Peoples R China
2.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China
3.Dongguan Univ Technol, Sch Mech Engn, Dongguan 523808, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Shanshan,Wan, Peng,Zhang, Bingchun,et al. Facile fabrication of the zoledronate-incorporated coating on magnesium alloy for orthopaedic implants[J]. JOURNAL OF ORTHOPAEDIC TRANSLATION,2020,22:2-6.
APA Chen, Shanshan,Wan, Peng,Zhang, Bingchun,Yang, Ke,&Li, Yuhai.(2020).Facile fabrication of the zoledronate-incorporated coating on magnesium alloy for orthopaedic implants.JOURNAL OF ORTHOPAEDIC TRANSLATION,22,2-6.
MLA Chen, Shanshan,et al."Facile fabrication of the zoledronate-incorporated coating on magnesium alloy for orthopaedic implants".JOURNAL OF ORTHOPAEDIC TRANSLATION 22(2020):2-6.

入库方式： OAI收割

来源：金属研究所

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