Electroactive barium titanate coated titanium scaffold improves osteogenesis and osseointegration with low-intensity pulsed ultrasound for large segmental bone defects
文献类型：期刊论文
| 作者 | Fan, Bo1,5; Guo, Zheng1; Li, Xiaokang1; Li, Songkai5; Gao, Peng3,4; Xiao, Xin1; Wu, Jie1; Shen, Chao1; Jiao, Yilai2; Hou, Wentao2 |
| 刊名 | BIOACTIVE MATERIALS
 |
| 出版日期 | 2020-12-01 |
| 卷号 | 5期号:4页码:1087-1101 |
| 关键词 | Large segmental bone defect Barium titanate Piezoelectric ceramic Porous Ti6Al4V scaffold Osteogenesis |
| DOI | 10.1016/j.bioactmat.2020.07.001 |
| 通讯作者 | Guo, Zheng(guozheng@fmmu.edu.cn) |
| 英文摘要 | For large segmental bone defects, porous titanium scaffolds have some advantages, however, they lack electrical activity which hinders their further use. In this study, a barium titanate (BaTiO3) piezoelectric ceramic was used to modify the surface of a porous Ti6Al4V scaffold (pTi), which was characterized by scanning electron microscopy, energy dispersive spectroscopy, X-ray photoelectron spectroscopy, and roughness and water contact angle analyses. Low intensity pulsed ultrasound (LIPUS) was applied in vitro and in vivo study. The activity of bone marrow mesenchymal stem cells, including adhesion, proliferation, and gene expression, was significantly superior in the BaTiO3/pTi, pTi + LIPUS, and BaTiO3/pTi + LIPUS groups than in the pTi group. The activity was also higher in the BaTiO3/pTi + LIPUS group than in the BaTiO3/pTi and pTi + LIPUS groups. Additionally, micro-computed tomography, the mineral apposition rate, histomorphology, and the peak pull-out load showed that these scaffold conditions significantly enhanced osteogenesis and osseointegration 6 and 12 weeks after implantation in large segmental bone defects in the radius of rabbits compared with those resulting from the pTi condition. Consequently, the improved osteogenesis and osseointegration make the BaTiO3/pTi + LIPUS a promising method to promote bone regeneration in large segmental bone defects for clinical application. |
| 资助项目 | National Key Research and Development Program of China[2017YFC1104901] ; National Natural Science Foundation of China[51771227] ; National Natural Science Foundation of China[31800812] ; Youth Development Program of Chinese People's Liberation Army[20QNPY069] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000562478100030 |
| 出版者 | KEAI PUBLISHING LTD |
| 资助机构 | National Key Research and Development Program of China ; National Natural Science Foundation of China ; Youth Development Program of Chinese People's Liberation Army |
| 源URL | [http://ir.imr.ac.cn/handle/321006/140307]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Guo, Zheng |
| 作者单位 | 1.Fourth Mil Med Univ, Xijing Hosp, Dept Orthoped, Xian 710032, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China 3.Hunan Normal Univ, Affiliated Hosp 1, Hunan Prov Peoples Hosp, Changsha 410016, Peoples R China 4.Hunan Normal Univ, Dept Joint Surg & Sports Med, Hunan Prov Peoples Hosp, Changsha 410016, Peoples R China 5.940 Hosp Joint Logist Support Force Chinese Peopl, Orthoped Ctr Spine Surg, Lanzhou 730050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Bo,Guo, Zheng,Li, Xiaokang,et al. Electroactive barium titanate coated titanium scaffold improves osteogenesis and osseointegration with low-intensity pulsed ultrasound for large segmental bone defects[J]. BIOACTIVE MATERIALS,2020,5(4):1087-1101. |
| APA | Fan, Bo.,Guo, Zheng.,Li, Xiaokang.,Li, Songkai.,Gao, Peng.,...&Hou, Wentao.(2020).Electroactive barium titanate coated titanium scaffold improves osteogenesis and osseointegration with low-intensity pulsed ultrasound for large segmental bone defects.BIOACTIVE MATERIALS,5(4),1087-1101. |
| MLA | Fan, Bo,et al."Electroactive barium titanate coated titanium scaffold improves osteogenesis and osseointegration with low-intensity pulsed ultrasound for large segmental bone defects".BIOACTIVE MATERIALS 5.4(2020):1087-1101. |
入库方式： OAI收割
来源：金属研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。