In vitro degradation and biocompatibility evaluation of fully biobased thermoplastic elastomers consisting of poly(beta-myrcene) and poly(L-lactide) as stent coating
文献类型：期刊论文
| 作者 | Wei, Zhiyong2; Wang, Wenhuan2; Zhou, Cheng2; Jin, Chenhao2; Leng, Xuefei2; Li, Yang2; Zhang, Xing1,3; Chen, Shanshan3; Zhang, Bingchun3; Yang, Ke3 |
| 刊名 | POLYMER DEGRADATION AND STABILITY
 |
| 出版日期 | 2020-09-01 |
| 卷号 | 179页码:10 |
| ISSN号 | 0141-3910 |
| 关键词 | Drug eluting stent Coating Poly(beta-myrcene)-poly(L-lactide) Thermoplastic elastomers |
| DOI | 10.1016/j.polymdegradstab.2020.109254 |
| 通讯作者 | Leng, Xuefei(lengxuefei@dlut.edu.cn) ; Chen, Shanshan(sschen@imr.ac.cn) |
| 英文摘要 | Currently coronary stent coating materials focus on biodegradable polymers requiring excellent performances, including biodegradability, cytocompatibility and hemocompatibility as well as ductility. To endow poly(L-lactide) (PLLA) with good ductility as stent coating, two kinds of high branched PLLA grafted copolymers with introduction of biobased poly(beta-myrcene) rubber segments were developed towards sent coating. The impacts of topological architectures (including linear comb and star comb) on physical properties, hydrolytic and enzymatic degradation behaviors, cytocompatibility, hemocompatibility and coating morphology were investigated. It was found that the nonbiodegradable poly(beta-myrcene) rubber segments delayed the degradation rate, and further decreased with more complex architectures. Proteinase K accelerated enzymatic degradation compared with hydrolytic degradation. Biocompatibility testing showed that the fully biobased thermoplastic elastomers possessed good cytocompatibility and hemocompatibility. Morphological characterization of stent coatings indicated that the linear comb and star comb PLLA grafted copolymers improved the surface smooth of pure PLLA coating. Thus, these highly branched fully biobased thermoplastic elastomers are promising to as potential coating materials in drug eluting stent. (C) 2020 Elsevier Ltd. All rights reserved. |
| 资助项目 | National Key R&D Program of China[2018YFC1105500 (2018YFC1105503)] ; Joint Research Fund Liaoning-Shenyang National Laboratory for Materials Science[20180510037] ; Fundamental Research Funds for the Central Universities[DUT19LAB27] |
| WOS研究方向 | Polymer Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000564499500004 |
| 资助机构 | National Key R&D Program of China ; Joint Research Fund Liaoning-Shenyang National Laboratory for Materials Science ; Fundamental Research Funds for the Central Universities |
| 源URL | [http://ir.imr.ac.cn/handle/321006/140434]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Leng, Xuefei; Chen, Shanshan |
| 作者单位 | 1.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Liaoning, Peoples R China 2.Dalian Univ Technol, Sch Chem Engn, Dept Polymer Sci & Engn, State Key Lab Fine Chem,Liaoning Key Lab Polymer, Dalian 116024, Peoples R China 3.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Zhiyong,Wang, Wenhuan,Zhou, Cheng,et al. In vitro degradation and biocompatibility evaluation of fully biobased thermoplastic elastomers consisting of poly(beta-myrcene) and poly(L-lactide) as stent coating[J]. POLYMER DEGRADATION AND STABILITY,2020,179:10. |
| APA | Wei, Zhiyong.,Wang, Wenhuan.,Zhou, Cheng.,Jin, Chenhao.,Leng, Xuefei.,...&Yang, Ke.(2020).In vitro degradation and biocompatibility evaluation of fully biobased thermoplastic elastomers consisting of poly(beta-myrcene) and poly(L-lactide) as stent coating.POLYMER DEGRADATION AND STABILITY,179,10. |
| MLA | Wei, Zhiyong,et al."In vitro degradation and biocompatibility evaluation of fully biobased thermoplastic elastomers consisting of poly(beta-myrcene) and poly(L-lactide) as stent coating".POLYMER DEGRADATION AND STABILITY 179(2020):10. |
入库方式： OAI收割
来源：金属研究所
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