In vitro differentiation of adipose-derived stem cells and bone marrow-derived stromal stem cells into neuronal-like cells
文献类型：期刊论文
| 作者 | Zhou Jin; Tian Guoping; Wang Jinge; Cong Xuefeng; Wu Xingkai; Zhang Siyang; Li Li; Xu Bing; Zhu Feng; Luo Xuedan |
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2011 |
| 卷号 | 6期号:19页码:1467-1472 |
| 关键词 | SELF-RENEWAL EXPRESSION TISSUE NANOG SOX2 PLURIPOTENCY MICRORNAS THERAPY LINEAGE OCT4 adipose-derived stem cells bone marrow-derived stromal stem cells differentiation neuron miR-125a-3p neural regeneration |
| ISSN号 | 1673-5374 |
| 其他题名 | In vitro differentiation of adipose-derived stem cells and bone marrow-derived stromal stem cells into neuronal-like cells |
| 英文摘要 | Adipose-derived stem cells and bone marrow-derived stromal stem cells were co-cultured with untreated or A beta(1-40)-treated PC12 cells, or grown in supernatant derived from untreated or A beta(1-40)-treated PC12 cells. Analysis by western blot and quantitative real-time PCR showed that protein levels of Nanog, Oct4, and Sox2, and mRNA levels of miR/125a/3p were decreased, while expression of insulin-like growth factor-2 and neuron specific enolase was increased. In comparison, the generation of neuron specific enolase-positive cells was most successful when adipose-derived stem cells were co-cultured with A beta(1-40)-treated PC12 cells. Our results demonstrate that adipose-derived stem cells and bone marrow-derived stromal stem cells exhibit trends of neuronal-like cell differentiation after co-culture with A beta(1-40)-treated PC12 cells. This process may relate to a downregulation of miR-125a-3p mRNA expression and increased levels of insulin-like growth factor-2 expression. |
| 资助项目 | [Shenyang Science and Technology Bureau] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4310629 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/141720]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Zhou Jin,Tian Guoping,Wang Jinge,et al. In vitro differentiation of adipose-derived stem cells and bone marrow-derived stromal stem cells into neuronal-like cells[J]. NEURAL REGENERATION RESEARCH,2011,6(19):1467-1472. |
| APA | Zhou Jin.,Tian Guoping.,Wang Jinge.,Cong Xuefeng.,Wu Xingkai.,...&Hu Fengjie.(2011).In vitro differentiation of adipose-derived stem cells and bone marrow-derived stromal stem cells into neuronal-like cells.NEURAL REGENERATION RESEARCH,6(19),1467-1472. |
| MLA | Zhou Jin,et al."In vitro differentiation of adipose-derived stem cells and bone marrow-derived stromal stem cells into neuronal-like cells".NEURAL REGENERATION RESEARCH 6.19(2011):1467-1472. |
入库方式： OAI收割
来源：金属研究所
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