High Performance Liquid Chromatographic Determination of Docetaxel in Human Serum Albumin Nanoparticles by Addition of Cysteine
文献类型：期刊论文
| 作者 | Lu Yi; Deng YiHui; Xu Huan; Shi Li; Dong XiaoHui; Li Le |
| 刊名 | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2008 |
| 卷号 | 36期号:9页码:1265-1268 |
| 关键词 | HUMAN PLASMA PACLITAXEL ASSAY Cysteine disulphide bonds human serum albumin nanoparticle high performance liquid chromatography |
| ISSN号 | 0253-3820 |
| 其他题名 | High Performance Liquid Chromatographic Determination of Docetaxel in Human Serum Albumin Nanoparticles by Addition of Cysteine |
| 英文摘要 | A method was established for the determination of docetaxel (DOC) in human serum albumin (HSA) nanoparticles by the addition of cysteine. The effect of cysteine (the disulphide bond breaker) on HSA disulphide bonds was monitored by the detection on the content of DOC from HSA-NP using HPLC. The measurements were performed on addition of 1 mu g/L free cysteine to the samples, the content assay of DOC were carried out after an incubation period of 30 min at 37 degrees C under continuous shaking. The results showed that the addition of cysteine significantly increased the release of DOC front HSA-NP, and the determination results of DOC were 10% higher than that of acetonitrile. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3399637 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/142814]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Lu Yi,Deng YiHui,Xu Huan,et al. High Performance Liquid Chromatographic Determination of Docetaxel in Human Serum Albumin Nanoparticles by Addition of Cysteine[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2008,36(9):1265-1268. |
| APA | Lu Yi,Deng YiHui,Xu Huan,Shi Li,Dong XiaoHui,&Li Le.(2008).High Performance Liquid Chromatographic Determination of Docetaxel in Human Serum Albumin Nanoparticles by Addition of Cysteine.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,36(9),1265-1268. |
| MLA | Lu Yi,et al."High Performance Liquid Chromatographic Determination of Docetaxel in Human Serum Albumin Nanoparticles by Addition of Cysteine".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 36.9(2008):1265-1268. |
入库方式： OAI收割
来源：金属研究所
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