Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia
文献类型：期刊论文
| 作者 | Xu Wangshu2; Sun Xuan4; Song Chengguang2; Mu Xiaopeng2; Ma Wenping1; Zhang Xinghu3; Zhao Chuansheng2 |
| 刊名 | Neural Regeneration Research
 |
| 出版日期 | 2016 |
| 卷号 | 11期号:5页码:745-751 |
| 关键词 | nerve regeneration Neurology. Diseases of the nervous system RC346-429 cerebral ischemia bumetanide Na + -K + -2Cl- cotransporter 1 hippocampal dentate gyrus neurogenesis neural precursor cells dendritic development cognitive function neural regeneration |
| ISSN号 | 1673-5374 |
| 其他题名 | Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia |
| 英文摘要 | Bumetanide has been shown to lessen cerebral edema and reduce the infarct area in the acute stage of cerebral ischemia. Few studies focus on the effects of bumetanide on neuroprotection and neurogenesis in the chronic stage of cerebral ischemia. We established a rat model of cerebral ischemia by injecting endothelin-1 in the left cortical motor area and left corpus striatum. Seven days later, bumetanide 200 μg/kg/day was injected into the lateral ventricle for 21 consecutive days with a mini-osmotic pump. Results demonstrated that the number of neuroblasts cells and the total length of dendrites increased, escape latency reduced, and the number of platform crossings increased in the rat hippocampal dentate gyrus in the chronic stage of cerebral ischemia. These findings suggest that bumetanide promoted neural precursor cell regeneration, dendritic development and the recovery of cognitive function, and protected brain tissue in the chronic stage of ischemia. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5715079 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/142874]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.北京大学 2.中国科学院金属研究所 3.Capital Med University, Beijing Tiantan Hosp, Dept Neurol, Neuroinfect & Neuroimmunol Ctr, Beijing, Peoples R China 4.Capital Med University, Beijing Tiantan Hosp, Dept Intervent Neuroradiol, Beijing, Peoples R China 5.China Med University, Benxi Cent Hosp, Dept Neurol, Benxi, Liaoning Provin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu Wangshu,Sun Xuan,Song Chengguang,et al. Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia[J]. Neural Regeneration Research,2016,11(5):745-751. |
| APA | Xu Wangshu.,Sun Xuan.,Song Chengguang.,Mu Xiaopeng.,Ma Wenping.,...&Zhao Chuansheng.(2016).Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia.Neural Regeneration Research,11(5),745-751. |
| MLA | Xu Wangshu,et al."Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia".Neural Regeneration Research 11.5(2016):745-751. |
入库方式： OAI收割
来源：金属研究所
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