Nasal mucosal inhalation of amyloid-beta peptide 3-10 defective adenovirus attenuates cytotoxicity induced by beta-amyloid (1-42)
文献类型：期刊论文
| 作者 | Jiang Tongzi; Guo Wanshu; Sha Sha; Xing Xiaona; Guo Rong; Cao Yunpeng |
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2014 |
| 卷号 | 9期号:8页码:872-877 |
| 关键词 | ALZHEIMERS-DISEASE TRANSGENIC MICE TANDEM REPEATS MOUSE MODEL IMMUNIZATION VACCINATION MEMORY IMMUNOTHERAPY ANTIBODIES DECLINE nerve regeneration neurodegenerative disease Alzheimer's disease immunotherapy amyloid-beta peptide vaccine cytokines humoral immunity inflammation NSFC grant neural regeneration |
| ISSN号 | 1673-5374 |
| 其他题名 | Nasal mucosal inhalation of amyloid-beta peptide 3–10 defective adenovirus attenuates cytotoxicity induced by beta-amyloid (1–42) |
| 英文摘要 | Three-month-old Alzheimer's disease model transgenic mice were immunized with A beta Plp-Adenovirus Ad-X-CMV-(A beta(3-10))(10)-CpG AdCpG-(A beta(3-10))(10) or AdCpG virus fluid via nasal mucosal inhalation, respectively. ELISA analysis of serum showed A beta(42) antibody titers were significantly increased in mice immunized with A beta(1-42) and AdCpG-(A beta(3-10))(10). Concanavalin A and AdCpG-(A beta(3-10))(10) stimulation significantly increased the number of proliferating spleen cells cultured from AdCpG(A beta(3-10))(10) and A beta(42) groups compared with the control group. In the AdCpG(A beta(3-10))(10) group, levels of interleukin (IL)-4 and IL-10 were increased, while those of IL-2 and interferon-gamma were decreased. In the A beta(42) group, levels of IL-4, IL-10, IL-2 and interferon-gamma were all increased. Experimental findings indicate that AdCpG-(A beta(3-10))(10) vaccine can produce strong T helper 2 (Th2) humoral immune responses in addition to the production of A beta(42) antibody. The cellular immunologic response was weak and avoided A beta(1-42)-mediated cytotoxicity. |
| 资助项目 | [National Natural Science Foundation of China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5135520 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/143058]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Jiang Tongzi,Guo Wanshu,Sha Sha,et al. Nasal mucosal inhalation of amyloid-beta peptide 3-10 defective adenovirus attenuates cytotoxicity induced by beta-amyloid (1-42)[J]. NEURAL REGENERATION RESEARCH,2014,9(8):872-877. |
| APA | Jiang Tongzi,Guo Wanshu,Sha Sha,Xing Xiaona,Guo Rong,&Cao Yunpeng.(2014).Nasal mucosal inhalation of amyloid-beta peptide 3-10 defective adenovirus attenuates cytotoxicity induced by beta-amyloid (1-42).NEURAL REGENERATION RESEARCH,9(8),872-877. |
| MLA | Jiang Tongzi,et al."Nasal mucosal inhalation of amyloid-beta peptide 3-10 defective adenovirus attenuates cytotoxicity induced by beta-amyloid (1-42)".NEURAL REGENERATION RESEARCH 9.8(2014):872-877. |
入库方式： OAI收割
来源：金属研究所
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