Phase II metabolites of etofesalamide in filamentous fungi
文献类型：期刊论文
| 作者 | Huang HH; Ma GL; Sun YM; Li Q; Zhong DF |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2005 |
| 卷号 | 26期号:7页码:893-896 |
| 关键词 | CUNNINGHAMELLA-ELEGANS TRANSFORMATION etofesalamide Cunninghamella metabolite transformation mass spectrum analysis |
| ISSN号 | 1671-4083 |
| 其他题名 | Phase II metabolites of etofesalamide in filamentous fungi |
| 英文摘要 | Aim: To study phase II metabolites of etofesalamide in filamentous fungi. Methods: Seven fungi were screened to transform etofesalamide. The metabolites of etofesalamide were assayed using liquid chromatography coupled to mass spectrometry. The major metabolite was subject to enzymatic hydrolysis to confirm its structure. Results: Etofesalamide was converted into two phase II metabolites: glucoside and riboside conjugates. Glucoside conjugate was the major product with a yield greater than 90%; no phase I metabolites were detected. Conclusion: Glucoside and riboside conjugations of etofesalamide in filamentous fungi differ from the phase II metabolism of glucuronidation in mammals. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:2208856 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/143350]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Huang HH,Ma GL,Sun YM,et al. Phase II metabolites of etofesalamide in filamentous fungi[J]. ACTA PHARMACOLOGICA SINICA,2005,26(7):893-896. |
| APA | Huang HH,Ma GL,Sun YM,Li Q,&Zhong DF.(2005).Phase II metabolites of etofesalamide in filamentous fungi.ACTA PHARMACOLOGICA SINICA,26(7),893-896. |
| MLA | Huang HH,et al."Phase II metabolites of etofesalamide in filamentous fungi".ACTA PHARMACOLOGICA SINICA 26.7(2005):893-896. |
入库方式： OAI收割
来源：金属研究所
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