Design, Synthesis and Pharmacological Evaluation of Novel 4-Phenoxyquinoline Derivatives as Potential Antitumor Agents
文献类型：期刊论文
| 作者 | Hu Hao1; Jiang Mingyan1; Xie Lijun2; Hu Gang1; Zhang Cuirong1; Zhang Lixia1; Zhou Shunguang1; Zhang Meihui1; Gong Ping1 |
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2015 |
| 卷号 | 31期号:5页码:746-755 |
| 关键词 | MET KINASE INHIBITORS GROWTH-FACTOR RECEPTOR C-MET 6,7-DISUBSTITUTED-4-PHENOXYQUINOLINE DERIVATIVES BIOLOGICAL EVALUATION DISCOVERY MOIETY BEARING IDENTIFICATION 4-Phenoxyquinoline derivative Cytotoxic activity 3-Amino-2-cyano-acrylamide |
| ISSN号 | 1005-9040 |
| 其他题名 | Design, Synthesis and Pharmacological Evaluation of Novel 4-Phenoxyquinoline Derivatives as Potential Antitumor Agents |
| 英文摘要 | A series of novel 4-phenoxyquinoline derivatives containing 3-amino-2-cyano-acrylamide framework was designed and synthesized, and the in vitro cytotoxic activities of them against five cancer cell lines(HT-29, H460, A549, MKN-45, and U87MG) were evaluated. Most of the compounds exhibited moderate-to-significant cytotoxicity and high selectivity against one or more cell lines as compared with Foretinib. The studies of their preliminary structure-activity relationships(SARs) indicate that the compounds containing methyl groups, especially methyl groups at 4-position of the phenyl ring(moiety B) are more effective. Among them, compound 36 shows the most potent antitumor activities with IC50 values of 0.04, 0.09, 0.67, 0.39 and 1.10 mu mol/L against HT-29, H460, A549, MKN-45 and U87MG cell lines, respectively. |
| 资助项目 | [Program for Liaoning Innovative Research Team in University, China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5537994 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/144765]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国科学院金属研究所 2.Fujian Institute Microbiol, Fuzhou 350007, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu Hao,Jiang Mingyan,Xie Lijun,et al. Design, Synthesis and Pharmacological Evaluation of Novel 4-Phenoxyquinoline Derivatives as Potential Antitumor Agents[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2015,31(5):746-755. |
| APA | Hu Hao.,Jiang Mingyan.,Xie Lijun.,Hu Gang.,Zhang Cuirong.,...&Gong Ping.(2015).Design, Synthesis and Pharmacological Evaluation of Novel 4-Phenoxyquinoline Derivatives as Potential Antitumor Agents.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,31(5),746-755. |
| MLA | Hu Hao,et al."Design, Synthesis and Pharmacological Evaluation of Novel 4-Phenoxyquinoline Derivatives as Potential Antitumor Agents".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 31.5(2015):746-755. |
入库方式： OAI收割
来源：金属研究所
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