Chondroitinase ABC improves recovery of long sciatic nerve defects
文献类型：期刊论文
| 作者 | Yu Hailong1; Xiang Liangbi1; Xu Wenjing2; Zhao Bin2; Wang Yu2; Peng Jiang2; Lu Shibi2 |
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2012 |
| 卷号 | 7期号:1页码:61-65 |
| 关键词 | GROWTH-FACTOR SULFATE PROTEOGLYCAN CHEMICAL-EXTRACTION LOCAL RELEASE REGENERATION GRAFTS REPAIR RAT chondroitinase ABC neural regeneration peripheral nerve sciatic nerve Schwann cell |
| ISSN号 | 1673-5374 |
| 其他题名 | Chondroitinase ABC improves recovery of long sciatic nerve defects ☆ |
| 英文摘要 | Sciatic nerves from allogeneic Sprague-Dawley rats were pretreated with chondroitinase ABC and were used to bridge damaged sciatic nerves in Wistar rats. Chondroitin sulfate proteoglycans were removed from the chemically extracted acellular nerves. At 3 months after grafting, the footplate pinch test result was positive in the Wistar rats. Autotomy scores decreased, and increased muscular contraction tension appeared when triceps surae muscles were stimulated. In addition, the recovery rate of wet triceps surae muscle weight increased, and the distal segment of the chondroitinase ABC-treated graft exhibited Schwann cells next to the nerve fibers. These results suggested that chondroitinase ABC pretreatment enhanced repair of long nerve defects via acellular nerve grafting. |
| 资助项目 | [Liaoning Scientific Research Foundation of Doctor] ; [Beijing Natural Science Foundation] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4439030 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/144910]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国科学院金属研究所 2.Chinese PLA, Institute Orthoped, Gen Hosp, Beijing 100853, Peoples R China Institute Orthoped Gen Hosp |
| 推荐引用方式 GB/T 7714 | Yu Hailong,Xiang Liangbi,Xu Wenjing,et al. Chondroitinase ABC improves recovery of long sciatic nerve defects[J]. NEURAL REGENERATION RESEARCH,2012,7(1):61-65. |
| APA | Yu Hailong.,Xiang Liangbi.,Xu Wenjing.,Zhao Bin.,Wang Yu.,...&Lu Shibi.(2012).Chondroitinase ABC improves recovery of long sciatic nerve defects.NEURAL REGENERATION RESEARCH,7(1),61-65. |
| MLA | Yu Hailong,et al."Chondroitinase ABC improves recovery of long sciatic nerve defects".NEURAL REGENERATION RESEARCH 7.1(2012):61-65. |
入库方式： OAI收割
来源：金属研究所
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