Pharmacokinetics of loratadine and its active metabolite descarboethoxyloratadine in healthy Chinese subjects
文献类型：期刊论文
| 作者 | Zhang YF1; Chen XY1; Zhong DF1; Dong YM1 |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2003 |
| 卷号 | 24期号:7页码:715-718 |
| 关键词 | loratadine descarboethoxyloratadine pharmacokinetics mass spectrum analysis |
| ISSN号 | 1671-4083 |
| 其他题名 | Pharmacokinetics of loratadine and its active metabolite descarboethoxyloratadine in healthy Chinese subjects |
| 英文摘要 | AIM: To investigate the pharmacokinetics of loratadine (LOR) and its active metabolite descarboethoxyloratadine (DCL) in healthy Chinese subjects. METHODS: Twenty healthy Chinese male subjects received a single oral dose of LOR 20 mg. A sensitive liquid chromatography-tandem mass spectrometry method (LC/MS/MS) was used for the determination of LOR and DCL in plasma. RESULTS: Mean maximum concentration (C.) was found (17 14) mug/L for LOR at 1.2 h and (16+/-9) mug/L for DCL at 1.5 h. Mean area under the plasma concentration-time curve from zero to infinity (AUC(0-infinity)) was (47+/-49) gg-h-L(-1) for LOR and (181+/-22) mug.h.L(-1) for DCL, respectively. The apparent elimination half-life (T(1/2)) of LOR was (6+/-4) h, and that of DCL was (13.4+/-2.6) h. The ratios of AUC(DCL)/AUC(LOR) ranged from 0.36 to 54.5. CONCLUSION: LOR was rapidly absorbed and transformed to DCL. AUC of the parent drug was extremely variable, while AUC of the active metabolite DCL was moderately variable after an oral dose of LOR to Chinese subjects. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:1273308 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/145049]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国科学院金属研究所 2.Peoples Hosp Liaoning Prov |
| 推荐引用方式 GB/T 7714 | Zhang YF,Chen XY,Zhong DF,et al. Pharmacokinetics of loratadine and its active metabolite descarboethoxyloratadine in healthy Chinese subjects[J]. ACTA PHARMACOLOGICA SINICA,2003,24(7):715-718. |
| APA | Zhang YF,Chen XY,Zhong DF,&Dong YM.(2003).Pharmacokinetics of loratadine and its active metabolite descarboethoxyloratadine in healthy Chinese subjects.ACTA PHARMACOLOGICA SINICA,24(7),715-718. |
| MLA | Zhang YF,et al."Pharmacokinetics of loratadine and its active metabolite descarboethoxyloratadine in healthy Chinese subjects".ACTA PHARMACOLOGICA SINICA 24.7(2003):715-718. |
入库方式： OAI收割
来源：金属研究所
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