Early diagnosis of epithelial ovarian cancer with cDNA microarry
文献类型：期刊论文
| 作者 | Chen Ying1; Zheng Huachuan2; Zhao Yujie1; Xin Yan1 |
| 刊名 | CHINESE JOURNAL OF CANCER RESEARCH
 |
| 出版日期 | 2008 |
| 卷号 | 20期号:2页码:110-114 |
| 关键词 | TUMOR PROGRESSION CELLS genes cDNA microarray early diagnosis |
| ISSN号 | 1000-9604 |
| 其他题名 | Early diagnosis of epithelial ovarian cancer with cDNA microarry |
| 英文摘要 | Objective: To investigate the roles of tumor suppressor genes-PTEN, nm23H(1), VEGF(165), Tiam1, MMP-2, Timp2, HE4 and S100A4 in tumorigenesis and progression of epithelial ovarian cancer(EOC) and develop a novel method for the early diagnosis of EOC. Methods: We observed the different expression profiles of those genes in normal ovary(n=5) and ovarian cancer tissue (n=20) by cDNA microarray. Results: In EOC, PTEN, Timp2 and nm23H1 genes were down-regulated (CY-3/CY-50.5), compared with the normal ovary, whereas Tiam1, VEGF165, MMP- 2, HE4 and S100A4 genes were up-regulated (CY-3/CY-5>2.0). Among them, HE4 gene was remarkably elevated (CY-3/CY-5>5.0). Their expression was correlated with clinicopathological staging of EOC(P<0.01). Conclusion: Those genes are closely linked to the pathogenesis and progression of EOC. cDNA microarray is an effective technique to screen molecular biological markers and predict the metastastic potential of EOC in early diagnosis. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3299651 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/145845]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国科学院金属研究所 2.中国科学院地质与地球物理研究所 |
| 推荐引用方式 GB/T 7714 | Chen Ying,Zheng Huachuan,Zhao Yujie,et al. Early diagnosis of epithelial ovarian cancer with cDNA microarry[J]. CHINESE JOURNAL OF CANCER RESEARCH,2008,20(2):110-114. |
| APA | Chen Ying,Zheng Huachuan,Zhao Yujie,&Xin Yan.(2008).Early diagnosis of epithelial ovarian cancer with cDNA microarry.CHINESE JOURNAL OF CANCER RESEARCH,20(2),110-114. |
| MLA | Chen Ying,et al."Early diagnosis of epithelial ovarian cancer with cDNA microarry".CHINESE JOURNAL OF CANCER RESEARCH 20.2(2008):110-114. |
入库方式： OAI收割
来源：金属研究所
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