Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities
文献类型:期刊论文
作者 | Mei YuDan1; Zhang Nan3; Zhang WeiYang4; Tang JinShan1; Zhou Hua4; Yu Yang1; Yao XinSheng1 |
刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
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出版日期 | 2019 |
卷号 | 17期号:1页码:27-32 |
关键词 | TRITERPENOID SAPONINS GLYCOSIDES BUDS STEMS Lonicerae Flos Lonicera macranthoides Ursane-type nortriterpenes Anti-inflammation iNOS |
ISSN号 | 2095-6975 |
英文摘要 | The flower buds of Lonicera macranthoides (Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranthoides resulted in the isolation of 12 triterpenoids (1-12), including two new ursane-type nortriterpenes, 2 alpha, 24-dihydroxy-23-nor-ursolic acid (1) and 2 alpha, 4 alpha-dihydroxy-23-nor-ursolic acid (2). Their structures were established by multiple spectroscopic methods and comparison with literature data. All isolated compounds were evaluated for their anti-inflammatory effects in LPS-activated RAW264.7 cells. Compounds 1 and 2 exhibited inhibitory effects on iNOS at the concentration of 30 mu mol.L-1. |
资助项目 | [National Natural Science Foundation of China] ; [Science and Technology Planning Project of Guangdong Province] |
语种 | 英语 |
CSCD记录号 | CSCD:6416308 |
源URL | [http://ir.imr.ac.cn/handle/321006/146389] ![]() |
专题 | 金属研究所_中国科学院金属研究所 |
作者单位 | 1.中国科学院广州地球化学研究所 2.暨南大学 3.中国科学院金属研究所 4.Macau University Sci & Technol, Fac Chinese Med, Macau 999078, Peoples R China Fac Chinese Med 5.Macau University Sci & Technol, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China State Key Lab Qual Res Chinese Med |
推荐引用方式 GB/T 7714 | Mei YuDan,Zhang Nan,Zhang WeiYang,et al. Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(1):27-32. |
APA | Mei YuDan.,Zhang Nan.,Zhang WeiYang.,Tang JinShan.,Zhou Hua.,...&Yao XinSheng.(2019).Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities.CHINESE JOURNAL OF NATURAL MEDICINES,17(1),27-32. |
MLA | Mei YuDan,et al."Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities".CHINESE JOURNAL OF NATURAL MEDICINES 17.1(2019):27-32. |
入库方式: OAI收割
来源:金属研究所
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