Syntheses and Antiproliferative Activities of Novel Diarylthiosemicarbazide Derivatives
文献类型：期刊论文
| 作者 | Zhai Xin; He Ying; Yang Zhen; Gong Ping |
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2013 |
| 卷号 | 29期号:1页码:62-66 |
| 关键词 | KINASE INHIBITORS ANTITUMOR AGENTS DESIGN BENZIMIDAZOLES CYTOTOXICITY Thiosemicarbazide N-methylpicolinamide Antiproliferative activity |
| ISSN号 | 1005-9040 |
| 其他题名 | Syntheses and Antiproliferative Activities of Novel Diarylthiosemicarbazide Derivatives |
| 英文摘要 | A series of novel N-methylpicolinamide-moiety containing diarylthiosemicarbazide derivatives was prepared and evaluated for their in vitro antiproliferative activity against three cancer cell lines(human alveolar epithelial cell A549, human lung cancer cell 11460 and human colorectal cancer cell HT-29) by 3-(4,5-dimethyl)thiazolyl-diphenyltetrazoliumromide(MTT) assay. Six compounds(7b-7g) with halogen substituents exhibited preferable cytotoxicity against one or more cell lines in a low micromolar range. Especially, the most promising compound 7g exhibited remarkable antiproliferative activity with the IC50 values of 2.2, 1.8 and 5.2 mu mol/L against A549, 11460 and HT-29 cell lines respectively, which is comparable to sorafenib. |
| 资助项目 | [National Natural Science Foundation of China] ; [Science & Technology Project of Liaoning Province, China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4756394 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/146987]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Zhai Xin,He Ying,Yang Zhen,et al. Syntheses and Antiproliferative Activities of Novel Diarylthiosemicarbazide Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2013,29(1):62-66. |
| APA | Zhai Xin,He Ying,Yang Zhen,&Gong Ping.(2013).Syntheses and Antiproliferative Activities of Novel Diarylthiosemicarbazide Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,29(1),62-66. |
| MLA | Zhai Xin,et al."Syntheses and Antiproliferative Activities of Novel Diarylthiosemicarbazide Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 29.1(2013):62-66. |
入库方式： OAI收割
来源：金属研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。