The cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis
文献类型：期刊论文
| 作者 | Xu Hui1; Yuan ShuiQiao1; Zheng ZhiHong1; Yan Wei1 |
| 刊名 | ASIAN JOURNAL OF ANDROLOGY
 |
| 出版日期 | 2013 |
| 卷号 | 15期号:6页码:799-805 |
| 关键词 | HUMAN SPERMATOZOA ALKALINE-PHOSPHATASE VOLUME REGULATION MALE-INFERTILITY LIFE-HISTORY RAT SPERMATOGENESIS EPIDIDYMIS ENZYMES MOUSE cytoplasmic droplets epididymis fertility mouse semen analysis spermiogenesis sperm motility |
| ISSN号 | 1008-682X |
| 其他题名 | The cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis |
| 英文摘要 | Although the cytoplasm of spermatids is removed at the end of spermiogenesis, a tiny portion is usually retained in the sperm flagellum, which is termed the cytoplasmic droplet (CD) in mammals. CDs are believed to play a role in sperm volume adaptation. However, we have noticed that epididymal spermatozoa that display initial (flagellation in situ) and progressive motility mostly possess CDs, whereas spermatozoa without CDs are rarely motile, suggesting that CDs have a role in motility development during sperm epididymal maturation. In the present study, we analyzed the relationship between the presence or absence of CDs, motility development and positional changes of CDs during sperm epididymal maturation in mice and monkeys. We also examined CDs on spermatozoa of three knockout mouse lines with late spermiogenic defects. Our data suggest that the CD is a normal organelle transiently present exclusively on epididymal spermatozoa, and normal CD morphology and location are associated with normal motility development during epididymal maturation of spermatozoa. Abnormal CD formation, e.g., a complete lack of CDs or ectopic CDs, is indicative of defective spermiogenesis. If CDs are essential for sperm motility development, then CDs may represent an ideal drug target for the development of non-hormonal male contraceptives. |
| 资助项目 | [startup funds from the University of Nevada, Reno] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4960262 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/147137]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国科学院金属研究所 2.华东师范大学 |
| 推荐引用方式 GB/T 7714 | Xu Hui,Yuan ShuiQiao,Zheng ZhiHong,et al. The cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis[J]. ASIAN JOURNAL OF ANDROLOGY,2013,15(6):799-805. |
| APA | Xu Hui,Yuan ShuiQiao,Zheng ZhiHong,&Yan Wei.(2013).The cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis.ASIAN JOURNAL OF ANDROLOGY,15(6),799-805. |
| MLA | Xu Hui,et al."The cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis".ASIAN JOURNAL OF ANDROLOGY 15.6(2013):799-805. |
入库方式： OAI收割
来源：金属研究所
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