Synthesis and anti-tumor activity of novel amide derivatives of ursolic acid
文献类型：期刊论文
| 作者 | Liu Dan2; Meng Yanqiu1; Zhao Juan1; Chen Ligong2 |
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2008 |
| 卷号 | 24期号:1页码:42-46 |
| 关键词 | BETULINIC ACID HUMAN-MELANOMA CELLS INHIBITION APOPTOSIS DNA ursolic acid amide derivatives anti-tumor activity |
| ISSN号 | 1005-9040 |
| 其他题名 | Synthesis and Anti-tumor Activity of Novel Amide Derivatives of Ursolic Acid |
| 英文摘要 | Ursolic acid was modified at C3 and C28 position to obtain fourteen derivatives including twelve novel compounds, and their chemical structures were characterized by IR, H-1 NMR and MS. Cell growth inhibitory effects of the derivatives against Hela cell were evaluated by MTT assay. All these derivatives were found to have stronger cell growth inhibitory than their parent compound, ursolic acid. The derivatives with a substituted acetyl group at C3 hydroxyl group show better activities than those with an unsubstituted hydroxyl group. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3251191 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/147209]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国科学院金属研究所 2.Tianjin Univ, Coll Pharmaceut & Biotechnology, Tianjin 300072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu Dan,Meng Yanqiu,Zhao Juan,et al. Synthesis and anti-tumor activity of novel amide derivatives of ursolic acid[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2008,24(1):42-46. |
| APA | Liu Dan,Meng Yanqiu,Zhao Juan,&Chen Ligong.(2008).Synthesis and anti-tumor activity of novel amide derivatives of ursolic acid.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,24(1),42-46. |
| MLA | Liu Dan,et al."Synthesis and anti-tumor activity of novel amide derivatives of ursolic acid".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 24.1(2008):42-46. |
入库方式： OAI收割
来源：金属研究所
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