Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice
文献类型：期刊论文
| 作者 | Liu YL2; Liang JH2; Yan LD2; Su RB2; Wu CF2; Gong ZH2 |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2005 |
| 卷号 | 26期号:5页码:533-538 |
| 关键词 | DOPAMINE-RECEPTOR ANTAGONISTS CALCIUM-CHANNEL INHIBITORS BEHAVIORAL SENSITIZATION MORPHINE EXPRESSION ADDICTION COCAINE RATS BLOCKERS HEROIN l-tetrahydropalmatine oxycodone locomotor sensitization |
| ISSN号 | 1671-4083 |
| 其他题名 | Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice |
| 英文摘要 | Aim: Recent studies have shown that 1-tetrahydropalmatine (l-THP), an active component of Corydolis yanhusuo, can inhibit the development of the conditional place preference induced by opioid receptor agonists, but the effects of l-THP on locomotor sensitivity induced by opioid receptor agonists have not been documented. In the present study, the effects of l-THP on locomotor sensitization to oxycodone, which is an opioid receptor agonist, were studied. Methods: Mice treated daily for 7 d with 5 mg/kg oxycodone and challenged with the same dose after 5 days of washout showed locomotor sensitization. In order to study the effects of l-THP on locomotor sensitization induced by oxycodone, l-THP was administered at doses of 6.25, 12.5, and 18.75 mg/kg, 40 min prior to treatment of oxycodone. Results: l-THP per se did not affect the locomotor activity at the doses of 6.25, 12.5, and 18.75 mg/kg, but could antagonize the hyperactivity induced by oxycodone (5 mg/kg). Co-administration of l-THP (18.75 mg/kg), 40 min prior to oxycodone, could inhibit the development of sensitization to oxycodone. In addition, l-THP (6.25, 12.5, and 18.75 mg/kg, ig) dose-dependently prevented the expression of oxycodone sensitization. Conclusion: These results suggested that l-THP could attenuate the locomotor-stimulating effects of oxycodone and inhibit the development and expression of oxycodone behavioral sensitization. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:2038650 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/147303]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国科学院金属研究所 2.Beijing Institute Pharmacol & Toxicol 3.北京大学 |
| 推荐引用方式 GB/T 7714 | Liu YL,Liang JH,Yan LD,et al. Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice[J]. ACTA PHARMACOLOGICA SINICA,2005,26(5):533-538. |
| APA | Liu YL,Liang JH,Yan LD,Su RB,Wu CF,&Gong ZH.(2005).Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice.ACTA PHARMACOLOGICA SINICA,26(5),533-538. |
| MLA | Liu YL,et al."Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice".ACTA PHARMACOLOGICA SINICA 26.5(2005):533-538. |
入库方式： OAI收割
来源：金属研究所
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