Tanshinone IIA inhibits endothelin-1 production in TNF-α-induced brain microvascular endothelial cells through suppression of endothelin-converting enzyme-1 synthesis
文献类型：期刊论文
| 作者 | Chao TANG1; Anhua WU1; Hongli XUE2; Yunjie WANG1 |
| 刊名 | Acta Pharmacologica Sinica
 |
| 出版日期 | 2007 |
| 卷号 | 28期号:8页码:1116-1122 |
| 关键词 | tanshinone IIA endothelin-1 TNF-α brain microvascular endothelial cells |
| ISSN号 | 1671-4083 |
| 其他题名 | Tanshinone IIA inhibits endothelin-1 production in TNF-α-induced brain microvascular endothelial cells through suppression of endothelin-converting enzyme-1 synthesis |
| 英文摘要 | To investigate the effects of tanshinone IIA (Tan IIA) on the regulation of the production of endothelin (ET)-1 (including large ET-1), mRNA levels of ET-1, endothelin-converting enzyme-1 (ECE-1), endothelin-A receptor (ET_A) and endothelin-B receptor (ETB) induced by TNF-α in rat brain microvascular endothelial cells (BMVEC). Methods: The ET-1 release (including large ET-1) into the culture medium was determined by enzyme immunoassay. The levels of ET-1, ECE-1, ET_A, and ETB mRNA were measured by RT-PCR. Endothelin receptor binding was also tested. Results: The induction of ET-1 release by TNF-α from cultured BMVEC was dose-dependently reduced by Tan IIA, but large ET-1 levels progressively increased in response to Tan IIA; the mRNA expression of ET-1 was unaffected. Tan IIA also caused a decrease in ET_A receptor mRNA and ECE-1 expression in a dose-dependent manner. Endothelin receptor binding was unaltered in BMVEC stimulated with TNF-α alone or a combination of TNF-α and Tan IIA. Conclusion: These findings suggest that Tan IIA may inhibit ET-1 production in TNF-α-induced BMVEC through the suppression of ECE-1 synthesis. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3088142 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/147356]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国医科大学 2.中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Chao TANG,Anhua WU,Hongli XUE,et al. Tanshinone IIA inhibits endothelin-1 production in TNF-α-induced brain microvascular endothelial cells through suppression of endothelin-converting enzyme-1 synthesis[J]. Acta Pharmacologica Sinica,2007,28(8):1116-1122. |
| APA | Chao TANG,Anhua WU,Hongli XUE,&Yunjie WANG.(2007).Tanshinone IIA inhibits endothelin-1 production in TNF-α-induced brain microvascular endothelial cells through suppression of endothelin-converting enzyme-1 synthesis.Acta Pharmacologica Sinica,28(8),1116-1122. |
| MLA | Chao TANG,et al."Tanshinone IIA inhibits endothelin-1 production in TNF-α-induced brain microvascular endothelial cells through suppression of endothelin-converting enzyme-1 synthesis".Acta Pharmacologica Sinica 28.8(2007):1116-1122. |
入库方式： OAI收割
来源：金属研究所
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