Synthesis and antitumor activities of a new series of 4,5-dihydro-1H-thiochromeno4,3-dpyrimidine derivatives
文献类型：期刊论文
| 作者 | Guo DeXiang; Liu YaJing; Li Ting; Wang Nan; Zhai Xin; Hu Chun; Gong Ping |
| 刊名 | SCIENCE CHINA-CHEMISTRY
 |
| 出版日期 | 2012 |
| 卷号 | 55期号:3页码:347-351 |
| 关键词 | heterocycle synthesis 4,5-dihydro-1H-thiochromeno4,3-dpyrimidine derivatives antitumor activity |
| ISSN号 | 1674-7291 |
| 其他题名 | Synthesis and antitumor activities of a new series of 4,5-dihydro-1H-thiochromeno4,3-dpyrimidine derivatives |
| 英文摘要 | A new series of 4,5-dihydro-1H-thiochromeno4,3-dpyrimidine derivatives have been designed and synthesized. The antitumor activities of the target compounds have been evaluated in vitro against two human cancer cell lines including A549 (human alveolar adenocarcinoma cell) and H460 (human lung cancer) by MTT assay. Most of the target compounds exhibited significant antitumor activities against A549 and H460 cancer cell lines. The most potent compound 4-(benzod1,3dioxol-5-yl)-8,9-difluoro-2-(4-methylpiperazin-1-yl)-4,5-dihydro-1H-thiochromeno4,3-dpyrimidine (CH05) (IC50 = 0.44 mu M, 3.07 mu M) was 2.0 and 8.4 times more active than gefitinib (IC50 = 0.89 mu M, 16.81 mu M) against A549 and H460 cell lines, respectively. |
| 资助项目 | [National Natural Science Foundation of China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4537942 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/147774]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Guo DeXiang,Liu YaJing,Li Ting,et al. Synthesis and antitumor activities of a new series of 4,5-dihydro-1H-thiochromeno4,3-dpyrimidine derivatives[J]. SCIENCE CHINA-CHEMISTRY,2012,55(3):347-351. |
| APA | Guo DeXiang.,Liu YaJing.,Li Ting.,Wang Nan.,Zhai Xin.,...&Gong Ping.(2012).Synthesis and antitumor activities of a new series of 4,5-dihydro-1H-thiochromeno4,3-dpyrimidine derivatives.SCIENCE CHINA-CHEMISTRY,55(3),347-351. |
| MLA | Guo DeXiang,et al."Synthesis and antitumor activities of a new series of 4,5-dihydro-1H-thiochromeno4,3-dpyrimidine derivatives".SCIENCE CHINA-CHEMISTRY 55.3(2012):347-351. |
入库方式： OAI收割
来源：金属研究所
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