Effect of dl-praeruptorin A on desmin and vimentin content in rat ischemia/reperfusion myocardiocytes
文献类型：期刊论文
| 作者 | Chang He1; Chu Xiaoyu2; Zou Jun3; Chang Tianhui2 |
| 刊名 | CHINESE MEDICAL JOURNAL
 |
| 出版日期 | 2007 |
| 卷号 | 120期号:24页码:2256-2259 |
| 关键词 | NECROSIS-FACTOR-ALPHA FACTOR-KAPPA-B PROTEIN DYSFUNCTION EXPRESSION HEART dl-praeruptorin A desmin vimentin intermediate filament ischemia myocardiocyte |
| ISSN号 | 0366-6999 |
| 其他题名 | Effect of dl-praeruptorin A on desmin and vimentin content in rat ischemia/reperfusion myocardiocytes |
| 英文摘要 | Background Intermediate filament (IF) proteins have been thought to play a role in nuclear centration, organelle movement and maintenance of cell shape. di-praeruptorin A (Pd-la), a novel Ca2+-influx blocker and K+-channel opener isolated from Chinese traditional herbal medicine Qian-Hu, has been demonstrated to inhibit expression of apoptosis related proteins and reduce the level of proinflammatory factors in ischemia/reperfusion myocardiocytes. Morphologically, whether Pd-la effects myocardiocyte IFs remains unclear. The purpose of this study was, for the first time, to evaluate the in vivo effects of Pd-la on IF desmin and vimentin content in order to further explore its cardioprotection against ischemia and elucidate its mechanism of action. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3189357 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/148009]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.新潟大学 2.中国科学院金属研究所 3.厦门大学 |
| 推荐引用方式 GB/T 7714 | Chang He,Chu Xiaoyu,Zou Jun,et al. Effect of dl-praeruptorin A on desmin and vimentin content in rat ischemia/reperfusion myocardiocytes[J]. CHINESE MEDICAL JOURNAL,2007,120(24):2256-2259. |
| APA | Chang He,Chu Xiaoyu,Zou Jun,&Chang Tianhui.(2007).Effect of dl-praeruptorin A on desmin and vimentin content in rat ischemia/reperfusion myocardiocytes.CHINESE MEDICAL JOURNAL,120(24),2256-2259. |
| MLA | Chang He,et al."Effect of dl-praeruptorin A on desmin and vimentin content in rat ischemia/reperfusion myocardiocytes".CHINESE MEDICAL JOURNAL 120.24(2007):2256-2259. |
入库方式： OAI收割
来源：金属研究所
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