Isoindolone derivative QSN-10c induces leukemic cell apoptosis and suppresses angiogenesis via PI3K/AKT signaling pathway inhibition
文献类型：期刊论文
| 作者 | Lv Wenwen; Qin Sining; Chen Congqin; Zhang Jinjie; Ren Tianshu; Xu Yongnan; Zhao Qingchun |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2014 |
| 卷号 | 35期号:5页码:625-635 |
| 关键词 | ENDOTHELIAL GROWTH-FACTOR DRUG-INDUCED APOPTOSIS HEMATOLOGICAL MALIGNANCIES ACTIN REORGANIZATION ANTICANCER DRUG BONE-MARROW KINASE AKT CANCER THALIDOMIDE MIGRATION isoindolone anticancer drug leukemia zebrafish angiogenesis apoptosis AKT GSK3 beta |
| ISSN号 | 1671-4083 |
| 其他题名 | Isoindolone derivative QSN-10c induces leukemic cell apoptosis and suppresses angiogenesis via PI3K/AKT signaling pathway inhibition |
| 英文摘要 | Aim: 2-(4,6-Dimethoxy-1,3-dioxoisoindolin-2-yl) ethyl 2-chloroacetate (QSN-10c) is one of isoindolone derivatives with antiproliferative activity against human umbilical vein endothelial cells (HUVECs). The aim of this study was to investigate its antitumor activity in vitro and anti-angiogenic effects in vitro and in vivo. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5142653 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/148132]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Lv Wenwen,Qin Sining,Chen Congqin,et al. Isoindolone derivative QSN-10c induces leukemic cell apoptosis and suppresses angiogenesis via PI3K/AKT signaling pathway inhibition[J]. ACTA PHARMACOLOGICA SINICA,2014,35(5):625-635. |
| APA | Lv Wenwen.,Qin Sining.,Chen Congqin.,Zhang Jinjie.,Ren Tianshu.,...&Zhao Qingchun.(2014).Isoindolone derivative QSN-10c induces leukemic cell apoptosis and suppresses angiogenesis via PI3K/AKT signaling pathway inhibition.ACTA PHARMACOLOGICA SINICA,35(5),625-635. |
| MLA | Lv Wenwen,et al."Isoindolone derivative QSN-10c induces leukemic cell apoptosis and suppresses angiogenesis via PI3K/AKT signaling pathway inhibition".ACTA PHARMACOLOGICA SINICA 35.5(2014):625-635. |
入库方式： OAI收割
来源：金属研究所
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