Design, synthesis and biological evaluation of novel glucokinase activators
文献类型：期刊论文
| 作者 | Li Yong Qiang2; Zhang Yu Liang3; Hu Sheng Quan3; Wang Yu Ling3; Song Hong Rui3; Feng Zhi Qiang2; Lei Lei2; Liu Quan2; Shen Zhu Fang2 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2011 |
| 卷号 | 22期号:1页码:73-76 |
| 关键词 | DISCOVERY POTENT Diabetes Glucokinase activators Benzamide derivatives |
| ISSN号 | 1001-8417 |
| 其他题名 | Design, synthesis and biological evaluation of novel glucokinase activators |
| 英文摘要 | A new series of benzamide derivatives as glucokinase activators (GKAs) were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure activity relationship (SAR) is discussed. The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675. (C) 2010 Zhi Qiang Feng. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| 资助项目 | [National Nature Science Foundation of China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4122342 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/148337]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.Peking Union Med Coll, Beijing 100050, Peoples R China 2.Chinese Acad Med Sci, Institute Mat Med, Beijing 100050, Peoples R China Institute Mat Med 3.中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Li Yong Qiang,Zhang Yu Liang,Hu Sheng Quan,et al. Design, synthesis and biological evaluation of novel glucokinase activators[J]. CHINESE CHEMICAL LETTERS,2011,22(1):73-76. |
| APA | Li Yong Qiang.,Zhang Yu Liang.,Hu Sheng Quan.,Wang Yu Ling.,Song Hong Rui.,...&Shen Zhu Fang.(2011).Design, synthesis and biological evaluation of novel glucokinase activators.CHINESE CHEMICAL LETTERS,22(1),73-76. |
| MLA | Li Yong Qiang,et al."Design, synthesis and biological evaluation of novel glucokinase activators".CHINESE CHEMICAL LETTERS 22.1(2011):73-76. |
入库方式： OAI收割
来源：金属研究所
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