Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism
文献类型：期刊论文
| 作者 | Yuan HengJie1; Chen DaWei3; Ren Yun1; Lou JianShi2 |
| 刊名 | ACTA CHIMICA SINICA
 |
| 出版日期 | 2008 |
| 卷号 | 66期号:21页码:2429-2433 |
| 关键词 | nitrendipine crystal polymorph conversion X-ray diffraction |
| ISSN号 | 0567-7351 |
| 其他题名 | Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism |
| 英文摘要 | Theoretical conversion temperature was calculated between different crystal forms of nitrendipine from melting data. The different conversion conditions were investigated, such as high temperature, high temperature and humidity and high pressure. The theoretical conversion temperature between nitrendipine I and II is 158.88 degrees C, that between nitrendipine I and III is 160.50 degrees C and that between nitrendipine II and III is 159.65 degrees C, indicating nitrendipine polymorphs belong to a monotropic system. At high temperature, nitrendipine II and III both converted to I. Under high pressure, II converted to I. The results indicate that nitrendipine I was a stable form, while II and III were metastable form. The stability ranked as I>II>III. Keywords nitrendipine; crystal polymorph; conversion; X-ray diffraction |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3459506 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/148537]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.Tianjin Med University, Gen Hosp, Dept Pharm, Tianjin 300052, Peoples R China 2.安徽肥东花生原种场 3.中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Yuan HengJie,Chen DaWei,Ren Yun,et al. Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism[J]. ACTA CHIMICA SINICA,2008,66(21):2429-2433. |
| APA | Yuan HengJie,Chen DaWei,Ren Yun,&Lou JianShi.(2008).Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism.ACTA CHIMICA SINICA,66(21),2429-2433. |
| MLA | Yuan HengJie,et al."Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism".ACTA CHIMICA SINICA 66.21(2008):2429-2433. |
入库方式： OAI收割
来源：金属研究所
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