Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae
文献类型：期刊论文
| 作者 | Zhang JingYi; Zhong HanYu; Shi GuoBing |
| 刊名 | CHINESE JOURNAL OF STRUCTURAL CHEMISTRY
 |
| 出版日期 | 2014 |
| 卷号 | 33期号:6页码:876-880 |
| 关键词 | ANTITUMOR-ACTIVITY DERIVATIVES 3,4,5-trimethoxyphenyl synthesis crystal structure antiproliferative activities |
| ISSN号 | 0254-5861 |
| 其他题名 | Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae |
| 英文摘要 | Many small-molecule compounds have been evaluated with potential antiproliferative activities. Ethyl 1-(phenylcarbamoyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylate, one novel cyclopropylamide analogue of combretastatin-A4 (CA-4), has been synthesized and its crystal structure was characterized by X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P2(1)/n, with a = 15.0263(3), b = 7.6574(2), c = 19.4117(4) angstrom, beta = 111.9010(10), V= 2072.36(8) angstrom(3), Z = 4, C22H24NO6, M-r = 398.42, D-c, = 1.277 Mg/cm(3), F(000) = 844, lambda(MoK alpha) = 1.54178 angstrom, mu = 0.770 mm(-1), R= 0.0546 and wR = 0.1889 for 3319 observed -reflections (I> 2 sigma(I)). Meanwhile, the compound revealed potential antiproliferative activities in several cancer cells in vitro. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5169669 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/148808]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Zhang JingYi,Zhong HanYu,Shi GuoBing. Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae[J]. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,2014,33(6):876-880. |
| APA | Zhang JingYi,Zhong HanYu,&Shi GuoBing.(2014).Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae.CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,33(6),876-880. |
| MLA | Zhang JingYi,et al."Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae".CHINESE JOURNAL OF STRUCTURAL CHEMISTRY 33.6(2014):876-880. |
入库方式： OAI收割
来源：金属研究所
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