Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats
文献类型：期刊论文
| 作者 | Wang Jun1; Cui Yan1; Ge Jing1; Ma Meijing2 |
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2012 |
| 卷号 | 7期号:25页码:1954-1959 |
| 关键词 | UTERINE PERFUSION-PRESSURE ARTERIAL-PRESSURE NITRIC-OXIDE PREGNANCY HOMOCYSTEINE DYSFUNCTION MODEL RISK MICE folic acid preeclampsia hyperhomocysteinemia proteinuria creatinine preeclampsia-like symptom pregnant rats offspring brain nervous system regeneration neural regeneration |
| ISSN号 | 1673-5374 |
| 其他题名 | Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats ☆ |
| 英文摘要 | Folic acid participates in the metabolism of homocysteine and lowers plasma homocysteine levels directly or indirectly. To establish a hyperhomocysteinennic pregnant rat model, 2 mL of DL-homocysteine was administered daily by intraperitoneal injection at a dose of 200 mg/kg from day 10 to day 19 of gestation. Folic acid was administered by intragastric administration at a dose of 20 mg/kg during the period of preeclampsia induction. Results showed that systolic blood pressure, proteinuria/creatinine ratio, and plasma homocysteine levels in the hyperhomocysteinemic pregnant rats increased significantly, and that body weight and brain weight of rat pups significantly decreased. Folic acid supplementation markedly reversed the above-mentioned abnormal changes of hyperhomocysteinemic pregnant rats and rat pups. These findings suggest that folic acid can alleviate the symptoms of hyperhomocysteinemia-induced preeclampsia in pregnant rats without influencing brain development of rat pups. |
| 资助项目 | [Medical Science and Technology Foundation of Chinese PLA] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4648164 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/149374]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国科学院金属研究所 2.Second Peoples Hosp Tongliao, Department Obstet & Gynaecol, Tongliao 280000, Inner Mongolia, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang Jun,Cui Yan,Ge Jing,et al. Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats[J]. NEURAL REGENERATION RESEARCH,2012,7(25):1954-1959. |
| APA | Wang Jun,Cui Yan,Ge Jing,&Ma Meijing.(2012).Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats.NEURAL REGENERATION RESEARCH,7(25),1954-1959. |
| MLA | Wang Jun,et al."Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats".NEURAL REGENERATION RESEARCH 7.25(2012):1954-1959. |
入库方式： OAI收割
来源：金属研究所
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