Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury
文献类型：期刊论文
| 作者 | Li Zhi1; Zhao Wei1; Liu Wei1; Zhou Ye1; Jia Jingqiao2; Yang Lifeng1 |
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2014 |
| 卷号 | 9期号:24页码:2197-2204 |
| 关键词 | AMNIOTIC MEMBRANE REPAIR nerve regeneration stem cells placenta-derived mesenchymal stem cells spinal cord injury neural stem cells nerve-like cells motor function sensory function neural regeneration |
| ISSN号 | 1673-5374 |
| 其他题名 | Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury |
| 英文摘要 | Because of their strong proliferative capacity and multi-potency, placenta-derived mesenchymal stem cells have gained interest as a cell source in the field of nerve damage repair. In the present study, human placenta-derived mesenchymal stem cells were induced to differentiate into neural stem cells, which were then transplanted into the spinal cord after local spinal cord injury in rats. The motor functional recovery and pathological changes in the injured spinal cord were observed for 3 successive weeks. The results showed that human placenta-derived mesenchymal stem cells can differentiate into neuron-like cells and that induced neural stem cells contribute to the restoration of injured spinal cord without causing transplant rejection. Thus, these cells promote the recovery of motor and sensory functions in a rat model of spinal cord injury. Therefore, human placenta-derived mesenchymal stem cells may be useful as seed cells during the repair of spinal cord injury. |
| 资助项目 | [Scientific Research Program of Liaoning Provincial Science and Technology Ministry in China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5325092 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/149603]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国科学院金属研究所 2.Liaoning Prov Wellcare Stem Cells Biotechnology Co L, Benxi, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Zhi,Zhao Wei,Liu Wei,et al. Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury[J]. NEURAL REGENERATION RESEARCH,2014,9(24):2197-2204. |
| APA | Li Zhi,Zhao Wei,Liu Wei,Zhou Ye,Jia Jingqiao,&Yang Lifeng.(2014).Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury.NEURAL REGENERATION RESEARCH,9(24),2197-2204. |
| MLA | Li Zhi,et al."Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury".NEURAL REGENERATION RESEARCH 9.24(2014):2197-2204. |
入库方式： OAI收割
来源：金属研究所
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