Synthesis and Tumor Cytotoxicity of Novel 1,2,3-Triazole-substituted 3-Oxo-oleanolic Acid Derivatives
文献类型：期刊论文
| 作者 | Li Fengran; Liu Yang; Wang Shuai; Wei Gaofei; Cheng Maosheng |
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2016 |
| 卷号 | 32期号:6页码:938-942 |
| 关键词 | OLEANOLIC ACID BIOLOGICAL EVALUATION AGENTS 3-Oxo-oleanolic acid 1,2,3-Triazole Tumor cytotoxicity |
| ISSN号 | 1005-9040 |
| 其他题名 | Synthesis and Tumor Cytotoxicity of Novel 1,2,3-Triazole-substituted 3-Oxo-oleanolic Acid Derivatives |
| 英文摘要 | Fifteen novel 3-oxo-oleanolic acid esters bearing aryl substituted 1,2,3-triazolyl methyl moiety were synthesized via the method of Copper(I)-catalyzed Huisgen cycloaddition. The cytotoxicity evaluation results of these compounds against five human tumor cell lines show that most of these compounds presented potent activity and selectivity against A375-S2 and HT1080 cells. Compound 6c, with a p-NO2 at the bezene ring, possesses the best inhibitory activity against A375-S2( IC50=2.82 mu mol/L) and HT1080( IC50= 1.69 mu mol/L). |
| 资助项目 | [National Natural Science Foundation of China] ; [Program for Liaoning Excellent Talents in University, China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5868625 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/149655]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Li Fengran,Liu Yang,Wang Shuai,et al. Synthesis and Tumor Cytotoxicity of Novel 1,2,3-Triazole-substituted 3-Oxo-oleanolic Acid Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2016,32(6):938-942. |
| APA | Li Fengran,Liu Yang,Wang Shuai,Wei Gaofei,&Cheng Maosheng.(2016).Synthesis and Tumor Cytotoxicity of Novel 1,2,3-Triazole-substituted 3-Oxo-oleanolic Acid Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,32(6),938-942. |
| MLA | Li Fengran,et al."Synthesis and Tumor Cytotoxicity of Novel 1,2,3-Triazole-substituted 3-Oxo-oleanolic Acid Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 32.6(2016):938-942. |
入库方式： OAI收割
来源：金属研究所
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