Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(V) Complexes with Hydrazones
文献类型：期刊论文
| 作者 | Zhao Yue1; Han Xiao2; Zhou XiaoXia1; Li HaiHua1; You ZhongLu1 |
| 刊名 | CHINESE JOURNAL OF INORGANIC CHEMISTRY
 |
| 出版日期 | 2013 |
| 卷号 | 29期号:4页码:867-874 |
| 关键词 | CRYSTAL-STRUCTURE COORDINATION CHEMISTRY METAL-COMPLEXES IN-VITRO LIGANDS DERIVATIVES CHELATORS AMMONIA SOIL hydrazone oxovanadium(V) complex crystal structure urease inhibitor |
| ISSN号 | 1001-4861 |
| 其他题名 | Synthesis,Structures,and Helicobacter Pylori Urease Inhibition of Oxovanadium(V) Complexes with Hydrazones |
| 英文摘要 | In order to explore new and efficient urease inhibitors, two new oxovanadium (V) complexes, VOL1 (OCH3)(CH3OH) (1) and VOL2(mu-OCH3)(2) (2) (H2L1=N'-(5-chloro-2-hydroxybenzylidene)-3-nitrobenzohydrazide; H2L2=N'-(5-chloro-2-hydroxybenzylidene)-4-chlorobenzohydrazide), have been synthesized and characterized by physico-chemical methods and single-crystal X-ray diffraction. Compound 1 is a mononuclear complex, and compound 2 is a bis-methanolato bridged centrosymmetric dinuclear complex. The V atom in each complex adopts an octahedral coordination. Thermal stability and urease inhibitory activities of the complexes were studied. The percent inhibition at the concentration of 100 mu mol . L-1 on Helicobacter pylori urease is 71.4% for 1 and 73.3% for 2. The IC50 values for 1 and 2 are 63.6 and 37.7 mu mol . L-1, respectively. CCDC: 858857, 1; and 858858, 2. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4833328 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/149825]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.辽宁师范大学 2.中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Zhao Yue,Han Xiao,Zhou XiaoXia,et al. Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(V) Complexes with Hydrazones[J]. CHINESE JOURNAL OF INORGANIC CHEMISTRY,2013,29(4):867-874. |
| APA | Zhao Yue,Han Xiao,Zhou XiaoXia,Li HaiHua,&You ZhongLu.(2013).Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(V) Complexes with Hydrazones.CHINESE JOURNAL OF INORGANIC CHEMISTRY,29(4),867-874. |
| MLA | Zhao Yue,et al."Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(V) Complexes with Hydrazones".CHINESE JOURNAL OF INORGANIC CHEMISTRY 29.4(2013):867-874. |
入库方式： OAI收割
来源：金属研究所
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