Discovery of Novel Tricyclic 5H-Pyridazino4,5-bindoles as Potent Antitumor Agents: Design, Synthesis and Biological Evaluation
文献类型：期刊论文
| 作者 | Zhai Xin; Wang Limei; Shi Jiyue; Gong Ping |
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2015 |
| 卷号 | 31期号:3页码:372-380 |
| 关键词 | TYROSINE KINASE INHIBITORS GROWTH-FACTOR RECEPTOR ANALOGS DERIVATIVES BINDING HARMINE 1-Anilino-5H-pyridazino4,5-bindole EGFR inhibitor Cytotoxicity |
| ISSN号 | 1005-9040 |
| 其他题名 | Discovery of Novel Tricyclic 5H-Pyridazino4,5-bindoles as Potent Antitumor Agents: Design,Synthesis and Biological Evaluation |
| 英文摘要 | A novel series of 5H-pyridazino4,5-bindoles(L-01-L-32) was synthesized and characterized by means of H-1 NMR, MS and elemental analysis. The cytotoxicity of the target compounds against Bel-7402 and HT-1080 cell lines were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay. Most of them exhibited moderate to excellent cytotoxicity, and six compounds(L-04, L-06, L-18, L-20, L-21 and L-23) possessed dramatically increased cytotoxicity superior to Gefitinib. Of these initial hits, compound L-21 displayed remarkable cytotoxicity against the tested cell lines with half maximal inhibitory concentration(IC50) values of 4.6 and 2.1 mu mol/L, respectively, which was 13.9- to 25.6-fold more potent than positive control. |
| 资助项目 | [National Natural Science Foundation of China] ; [Liaoning Baiqianwan Talents Program, China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5434854 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/150261]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Zhai Xin,Wang Limei,Shi Jiyue,et al. Discovery of Novel Tricyclic 5H-Pyridazino4,5-bindoles as Potent Antitumor Agents: Design, Synthesis and Biological Evaluation[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2015,31(3):372-380. |
| APA | Zhai Xin,Wang Limei,Shi Jiyue,&Gong Ping.(2015).Discovery of Novel Tricyclic 5H-Pyridazino4,5-bindoles as Potent Antitumor Agents: Design, Synthesis and Biological Evaluation.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,31(3),372-380. |
| MLA | Zhai Xin,et al."Discovery of Novel Tricyclic 5H-Pyridazino4,5-bindoles as Potent Antitumor Agents: Design, Synthesis and Biological Evaluation".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 31.3(2015):372-380. |
入库方式： OAI收割
来源：金属研究所
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