Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives
文献类型：期刊论文
| 作者 | Ren Li; Liu Yang; Yu Guihua; Gao Yuan; Liu Xin; Wang Bo; Deng Xiaonan; Cheng Maosheng |
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2014 |
| 卷号 | 30期号:4页码:639-643 |
| 关键词 | TRITERPENOID SAPONINS BEARING ALBIZIA-JULIBRISSIN DISACCHARIDE MOIETY BETA-HEDERIN RAIN-FOREST ANALOGS N-Substituted glucosamine-bearing triterpenoid saponin Tumor cytotoxicity Oleanolic acid |
| ISSN号 | 1005-9040 |
| 其他题名 | Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives |
| 英文摘要 | Eleven novel triterpenoid saponins, N-substituted-beta-D-glucosaminide derivatives of oleanolic acid, were designed and synthesized via a stepwise glycosylation strategy. These compounds were evaluated for in vitro cytotoxic activity against six different tumor cell lines. Most of the compounds inhibited the growth of, at least, one tumor cell line effectively at micromolar concentrations. Preliminary structure-activity relationships(SARs) indicate that acylation of the nitrogen of the glucosamine-bearing triterpenoid saponins affords the compounds that are highly cytotoxic towards specific tumor cell lines. |
| 资助项目 | [National Natural Science Foundation of China] ; [PhD Scientific Research Opening Foundation Projects of Liaoning Province of China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5214902 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/150347]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Ren Li,Liu Yang,Yu Guihua,et al. Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2014,30(4):639-643. |
| APA | Ren Li.,Liu Yang.,Yu Guihua.,Gao Yuan.,Liu Xin.,...&Cheng Maosheng.(2014).Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,30(4),639-643. |
| MLA | Ren Li,et al."Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 30.4(2014):639-643. |
入库方式： OAI收割
来源：金属研究所
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