Pharmacokinetic behaviors and oral bioavailability of oridonin in rat plasma
文献类型：期刊论文
| 作者 | Xu Wen1; Sun Jin1; Zhang TingTing1; Ma Bo1; Cui ShengMiao1; Chen DaWei1; He ZhongGui1 |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2006 |
| 卷号 | 27期号:12页码:1642-1646 |
| 关键词 | RABDOSIA-RUBESCENS SIGNAL PATHWAYS CELLS oridonin pharmacokinetics intravenous oral bioavailability intraperitoneal injections rats |
| ISSN号 | 1671-4083 |
| 其他题名 | Pharmacokinetic behaviors and oral bioavailability of oridonin in rat plasma |
| 英文摘要 | Aim: To study the intravenous and oral pharmacokinetic behavior of oridonin and its extent of absolute oral bioavailability in rats. Methods: Oridonin was administered to rats via iv (5,10 and 15 mg/kg), po (20,40 and 80 mg/kg) or ip administration (10 mg/kg). The concentrations of oridonin in rat plasma were determined by a high performance liquid chromatography with electrospray ionization mass spec-trometric detection (HPLC/ESI-MS) method and the pharmacokinetic parameters were determined by non-compartmental analysis. Results: The plasma concentration of oridonin after intravenous administration decreased polyexponentially, and the pharmacokinetic parameters of oridonin were dose-independent within the examined range. Oridonin was absorbed rapidly after oral gavage with a t(max) of less than 15 min; the extent of absolute bioavailability of oridonin following oral administration was 4.32%, 4.58% and 10.8%. The extent of absolute bioavailability of oridonin following intraperitoneal administration was 12.6%. Conclusion: First order rate pharmacokinetics were observed for oridonin within the range of iv doses, while the extent of absolute oral bioavailability was rather low and dose-dependent. The low and dose-dependent extent of oral bioavailability may be due to the saturation of first-pass effects. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:2618176 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/150908]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国科学院金属研究所 2.Guangdong Pharmaceut University |
| 推荐引用方式 GB/T 7714 | Xu Wen,Sun Jin,Zhang TingTing,et al. Pharmacokinetic behaviors and oral bioavailability of oridonin in rat plasma[J]. ACTA PHARMACOLOGICA SINICA,2006,27(12):1642-1646. |
| APA | Xu Wen.,Sun Jin.,Zhang TingTing.,Ma Bo.,Cui ShengMiao.,...&He ZhongGui.(2006).Pharmacokinetic behaviors and oral bioavailability of oridonin in rat plasma.ACTA PHARMACOLOGICA SINICA,27(12),1642-1646. |
| MLA | Xu Wen,et al."Pharmacokinetic behaviors and oral bioavailability of oridonin in rat plasma".ACTA PHARMACOLOGICA SINICA 27.12(2006):1642-1646. |
入库方式： OAI收割
来源：金属研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。