A fluorometric and mitochondrion-targetable probe for rapid, naked-eye test of hypochlorite in real samples
文献类型：期刊论文
| 作者 | Xia Ying1; Liu Xiaoyu1; Wang Dan1; Wang Zechen1; Liu Qiang1; Yu Haibo1; Zhang Mingyan2; Song Youtao1 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2018 |
| 卷号 | 29期号:10页码:1517-1520 |
| 关键词 | DISINFECTION BY-PRODUCTS SODIUM-HYPOCHLORITE FLUORESCENT-PROBE DRINKING-WATER PERACETIC-ACID WASTE-WATER OXIDATION MYELOPEROXIDASE CHEMOSENSORS GENOTOXICITY Colorimetric probe Fluorescent probe Rhodamine Hypochlorite Mitochondrion-tragetable |
| ISSN号 | 1001-8417 |
| 英文摘要 | Hypochlorite anion is a ubiquitous reactive molecule in the terminal disinfection systems, inflammatory stress and immune systems. Thus, rapid and visual monitoring ClO- in water and biological samples is very meaningful for water quality safety and toxicity assessment of contaminants. Herein, a colorimetric and fluorometric probe (Rh-GO) based on rhodamine B fluorophore and thiophene-2-carbohydrazide has been unveiled and successfully utilized for ClO- detection in water samples and HeLa cells. Upon addition of ClO-, color changes of solution from colorless to pink were immediately visible to the naked eyes, meanwhile, brilliant red fluorescence was observed under excited at UV light (365 nm). Rh-ClO displayed high selectivity and sensitivity for ClO-, and the detection limit was 7 mu mol/L calculated from the fluorescence titration. With the aid of its merits including rapid response to ClO- within 10 s, Rh-ClO and its test paper could successfully detect ClO- in water. Additionally, HeLa cells image co-stained with Rh-ClO and Rh123 demonstrated that Rh-ClO possessed excellent and fast cell-membrane permeability and mitochondrion-targetability. It was clearly confirmed that Rh-ClO would be a promising probe for rapid tracking of ClO- in water samples and in mitochondria of living cells. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| 资助项目 | [National Natural Science Foundation of China] ; [Liaoning Province Education Administration] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6346038 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/151313]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.辽宁大学 2.中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Xia Ying,Liu Xiaoyu,Wang Dan,et al. A fluorometric and mitochondrion-targetable probe for rapid, naked-eye test of hypochlorite in real samples[J]. CHINESE CHEMICAL LETTERS,2018,29(10):1517-1520. |
| APA | Xia Ying.,Liu Xiaoyu.,Wang Dan.,Wang Zechen.,Liu Qiang.,...&Song Youtao.(2018).A fluorometric and mitochondrion-targetable probe for rapid, naked-eye test of hypochlorite in real samples.CHINESE CHEMICAL LETTERS,29(10),1517-1520. |
| MLA | Xia Ying,et al."A fluorometric and mitochondrion-targetable probe for rapid, naked-eye test of hypochlorite in real samples".CHINESE CHEMICAL LETTERS 29.10(2018):1517-1520. |
入库方式： OAI收割
来源：金属研究所
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