Solid-phase synthesis of acyl-plasminogen-streptokinase activator composite(APSAC) and its thrombolytic properties
文献类型：期刊论文
| 作者 | Teng LR1; Liang F1; Sun H1; Qin Y1; Hong SS1; Chen J1; Liu LY1 |
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2004 |
| 卷号 | 20期号:5页码:584-587 |
| 关键词 | CONVERSION acyl-plasminogen-streptokinase activator complex (APSAC) solid-phase synthesis thrombolytic |
| ISSN号 | 1005-9040 |
| 其他题名 | Solid-phase Synthesis of Acyl-plasminogen-Streptokinase Activator Composite(APSAC) and Its Thrombolytic Properties |
| 英文摘要 | The dialysis method has been traditionally used for the conversion of native human plasminogen (Glu-Hpg) to lys-plasminogen(Lys-Hpg). Here is described a solid-phase synthesis method for. the preparation of an acyl-plasminogen-streptokinase activator complex (APSAC) from Lys-Hpg, streptokinase (SK) and chemical modification agent(4-amidinophenyl-4'-aminobenzoate hydrochloride) with the L-lysine-Sepharose 4B Column as the carrier. The new method significantly increases the product yield and purity over the liquid-phase methods. The APSAC prepared with the new method exhibits a significant thrombolytic effect with a long half-life of about 8.8 h in rabbits. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:1844816 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/151437]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.吉林大学 2.Institute Biol Prod 3.中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Teng LR,Liang F,Sun H,et al. Solid-phase synthesis of acyl-plasminogen-streptokinase activator composite(APSAC) and its thrombolytic properties[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2004,20(5):584-587. |
| APA | Teng LR.,Liang F.,Sun H.,Qin Y.,Hong SS.,...&Liu LY.(2004).Solid-phase synthesis of acyl-plasminogen-streptokinase activator composite(APSAC) and its thrombolytic properties.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,20(5),584-587. |
| MLA | Teng LR,et al."Solid-phase synthesis of acyl-plasminogen-streptokinase activator composite(APSAC) and its thrombolytic properties".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 20.5(2004):584-587. |
入库方式： OAI收割
来源：金属研究所
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