A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population
文献类型：期刊论文
| 作者 | Cui Hua5; Li Xiaoying5; Gao Xuewen6; Lu Xiang7; Wu Xiuping8; Wang Xiaofei9; Zheng Xiangqing10; Huang Kui11; Liu Feng12; Luo Zhi13 |
| 刊名 | CHINESE JOURNAL OF INTEGRATIVE MEDICINE
 |
| 出版日期 | 2019 |
| 卷号 | 25期号:10页码:728-735 |
| 关键词 | ACUTE CORONARY SYNDROME ASSOCIATION TASK-FORCE AMERICAN-COLLEGE DEPSIDE SALTS MILTIORRHIZA QUESTIONNAIRE INTERVENTION GUIDELINES MANAGEMENT ADULTS Salvianolate unstable angina pectoris elderly efficacy |
| ISSN号 | 1672-0415 |
| 其他题名 | A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population |
| 英文摘要 | Objective To evaluate the efficacy and safety of salvianolate in elderly patients with unstable angina pectoris (UAP). Methods A prospective double-blind randomized placebo-controlled multicenter trial in elderly patients with UAP from 13 third-grade class-A hospitals in China was performed. A total of 318 patients were randomly allocated in a 1:1 ratio to an experimental group (160 patients) and a control group (158 patients). The experimental group was treated with salvianolate for 14 days on the basis of conventional medicine, and the control group was given a placebo for 14 days with the same criteria. Follow-up was lasted 28 days in both groups. The primary endpoint was biweekly frequency of angina pectoris attacks. The secondary endpoints included biweekly dosage of nitroglycerin, the Seattle Angina Questionnaire, angina pectoris severity and duration, myocardial injury markers, high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), as well as major adverse cardiovascular events (MACEs). Safety was assessed according to adverse events and serious adverse events. Results Baseline characteristics were similar between treatment groups. Compared with those in the control group, the frequency of biweekly angina attacks (2.92 vs . 4.08, P=0.025), the biweekly dosage of nitroglycerin, as well as the severity and duration of angina attacks (P<0.01) were reduced by salvianolate. The Seattle Angina Questionnaire score was also significantly improved in the experimental group than in the control group (P<0.05). No significant differences were observed between the two groups with respect to the incidence of MACEs. Salvianolate was well tolerated. Conclusions Salvianolate appear to have efficacy and well tolerated for elderly patients with UAP. ClinicalTrials.gov identifier: NCT03037047 |
| 资助项目 | [Science and Technology Commission of Shanghai Municipality] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6573721 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/151500]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.吉林大学 2.Wenzhou Med University, Dept Cadre Hlth Care, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China 3.China Hlth Promot Fdn, Beijing 100161, Peoples R China 4.Shanghai Green Valley Pharmaceut Co Ltd, Med Department, Shanghai 201203, Peoples R China 5.Gen Hosp Peoples Liberat Army, Department Geriatr Cardiol, Beijing 100853, Peoples R China 6.Inner Mongolia Peoples Hosp, Department Geriatr Clin, Hohhot 010017, Peoples R China 7.中国科学院南京地理与湖泊研究所 8.Harbin Med University, Dept Cadres Ward 2, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China 9.Tianjin First Cent Hosp, Department Cadre Hlth Care, Tianjin 300192, Peoples R China 10.Chongqing Gen Hosp, Department Cardiovasc Med, Chongqing 400013, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui Hua,Li Xiaoying,Gao Xuewen,et al. A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population[J]. CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2019,25(10):728-735. |
| APA | Cui Hua.,Li Xiaoying.,Gao Xuewen.,Lu Xiang.,Wu Xiuping.,...&Zhang Wenju.(2019).A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population.CHINESE JOURNAL OF INTEGRATIVE MEDICINE,25(10),728-735. |
| MLA | Cui Hua,et al."A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population".CHINESE JOURNAL OF INTEGRATIVE MEDICINE 25.10(2019):728-735. |
入库方式： OAI收割
来源：金属研究所
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