Synthesis and Crystal Structure of (R)-1-acetyl-6-(2-chloro-4-fluorophenyl)-4-methyl-N-((R)-1-phenylethyl)-2-(2,4,6-trifluorophenyl)-1,6-dihydropyrimidine-5-carboxamide
文献类型：期刊论文
| 作者 | Yang XiuYan3; Zhao GuoMing1; Yang ShiYing4; Li Song1 |
| 刊名 | CHINESE JOURNAL OF STRUCTURAL CHEMISTRY
 |
| 出版日期 | 2013 |
| 卷号 | 32期号:7页码:989-992 |
| 关键词 | INHIBITION HAPs crystal structure synthesis |
| ISSN号 | 0254-5861 |
| 其他题名 | Synthesis and Crystal Structure of (R)-1-acetyl-6-(2-chloro-4-fluorophenyl)-4-methyl-N-((R)-1-phenylethyl)-2-(2,4,6-trifluorophenyl)-1,6-dihydropyrimidine-5-carboxamide |
| 英文摘要 | The crystal structure of the title compound (C28H22ClF4N3O2, M-r = 543.14) was determined by single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group P2(1) with a = 12.2113(11), b = 9.4956(9), c = 25.484(2) angstrom, beta = 98.486(1)degrees, V= 2922.6(5) angstrom, Z = 2, D-c = 1.302 Mg/m(3), F(000) = 1184, mu = 0.19 mm(-1), R = 0.068 and wR = 0.186. The asymmetric unit of the title compound contains two organic molecules and two solvent acetone molecules with 50% occupancy each. In each organic molecule, the dihydropyridine ring adopts a half boat conformation. In the crystal, the molecules are linked by N-H center dot center dot center dot O hydrogen bonds. |
| 资助项目 | [National Natural Science Foundation of China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4895382 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/151534]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.Acad Mil Med Sci, Institute Pharmacol & Toxicol, Beijing 100850, Peoples R China 2.Coll Med, Beijing 100050, Peoples R China 3.中国科学院金属研究所 4.Chinese Acad Med Sci, Institute Mat Med, Beijing 100050, Peoples R China Institute Mat Med |
| 推荐引用方式 GB/T 7714 | Yang XiuYan,Zhao GuoMing,Yang ShiYing,et al. Synthesis and Crystal Structure of (R)-1-acetyl-6-(2-chloro-4-fluorophenyl)-4-methyl-N-((R)-1-phenylethyl)-2-(2,4,6-trifluorophenyl)-1,6-dihydropyrimidine-5-carboxamide[J]. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,2013,32(7):989-992. |
| APA | Yang XiuYan,Zhao GuoMing,Yang ShiYing,&Li Song.(2013).Synthesis and Crystal Structure of (R)-1-acetyl-6-(2-chloro-4-fluorophenyl)-4-methyl-N-((R)-1-phenylethyl)-2-(2,4,6-trifluorophenyl)-1,6-dihydropyrimidine-5-carboxamide.CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,32(7),989-992. |
| MLA | Yang XiuYan,et al."Synthesis and Crystal Structure of (R)-1-acetyl-6-(2-chloro-4-fluorophenyl)-4-methyl-N-((R)-1-phenylethyl)-2-(2,4,6-trifluorophenyl)-1,6-dihydropyrimidine-5-carboxamide".CHINESE JOURNAL OF STRUCTURAL CHEMISTRY 32.7(2013):989-992. |
入库方式： OAI收割
来源：金属研究所
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