Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy
文献类型：期刊论文
| 作者 | Yang Xiaofeng; Xu Yifeng; Lue Naiwu; Zhang Yibin; Wang Hongmei; Lue Xin; Cui Jiping; Zhou Jinxu; Shan Hong; Wu Yanxiang |
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2011 |
| 卷号 | 6期号:10页码:785-789 |
| 关键词 | IN-VITRO ENDOTHELIAL-CELLS PROGENITOR CELLS CULTURE VIVO umbilical cord mesenchymal stem cells Duchenne muscular dystrophy case report dystrophin muscular force activities of daily living |
| ISSN号 | 1673-5374 |
| 其他题名 | Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy |
| 英文摘要 | Due to their relative abundance, stable biological properties and excellent reproductive activity, umbilical cord mesenchymal stem cells have previously been utilized for the treatment of Duchenne muscular dystrophy, which is a muscular atrophy disease. Three patients who were clinically and pathologically diagnosed with Duchenne muscular dystrophy were transplanted with umbilical cord mesenchymal stem cells by intravenous infusion, in combination with multi-point intramuscular injection. They were followed up for 12 months after cell transplantation. Results showed that clinical symptoms significantly improved, daily living activity and muscle strength were enhanced, the sero-enzyme, electromyogram, and MRI scans showed improvement, and dystrophin was expressed in the muscle cell membrane. Hematoxylin-eosin staining of a muscle biopsy revealed that muscle fibers were well arranged, fibrous degeneration was alleviated, and fat infiltration was improved. These pieces of evidence suggest that umbilical cord mesenchymal stem cell transplantation can be considered as a new regimen for Duchenne muscular dystrophy. |
| 资助项目 | [Key Projects of Liaoning Province] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4258073 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/151817]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Yang Xiaofeng,Xu Yifeng,Lue Naiwu,et al. Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy[J]. NEURAL REGENERATION RESEARCH,2011,6(10):785-789. |
| APA | Yang Xiaofeng.,Xu Yifeng.,Lue Naiwu.,Zhang Yibin.,Wang Hongmei.,...&Liu Xinping.(2011).Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy.NEURAL REGENERATION RESEARCH,6(10),785-789. |
| MLA | Yang Xiaofeng,et al."Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy".NEURAL REGENERATION RESEARCH 6.10(2011):785-789. |
入库方式： OAI收割
来源：金属研究所
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