Repair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors?
文献类型：期刊论文
| 作者 | Wang Yansong; Lue Gang |
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2010 |
| 卷号 | 5期号:17页码:1303-1307 |
| 关键词 | FUNCTIONAL RECOVERY CORTICOSPINAL NEURONS PROGENITOR CELLS ADULT RATS LONG-TERM TRANSPLANTATION EXPRESSION BDNF NGF DIFFERENTIATION neural stem cells brain-derived neurotrophic factor transplantation green fluorescent protein spinal cord injury neural regeneration |
| ISSN号 | 1673-5374 |
| 其他题名 | Repair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors |
| 英文摘要 | Brain-derived neurotrophic factor (BDNF) can significantly promote nerve regeneration and repair. High expression of the BDNF-green fluorescent protein (GFP) gene persists for a long time after transfection into neural stem cells. Nevertheless, little is known about the biological characteristics of BDNF-GFP modified nerve stem cells in vivo and their ability to induce BDNF expression or repair spinal cord injury. In the present study, we transplanted BDNF-GFP transgenic neural stem cells into a hemisection model of rats. Rats with BDNF-GFP stem cells exhibited significantly increased BDNF expression and better locomotor function compared with stem cells alone. Cellular therapy with BDNF-GFP transgenic stem cells can improve outcomes better than stem cells alone and may have therapeutic potential for spinal cord injury. |
| 资助项目 | [Natural Science Foundation of Liaoning Province] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4041465 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/151987]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Wang Yansong,Lue Gang. Repair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors?[J]. NEURAL REGENERATION RESEARCH,2010,5(17):1303-1307. |
| APA | Wang Yansong,&Lue Gang.(2010).Repair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors?.NEURAL REGENERATION RESEARCH,5(17),1303-1307. |
| MLA | Wang Yansong,et al."Repair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors?".NEURAL REGENERATION RESEARCH 5.17(2010):1303-1307. |
入库方式： OAI收割
来源：金属研究所
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