Effect of Continuous Positive Airway Pressure Therapy on Glycemic Excursions and Insulin Sensitivity in Patients with Obstructive Sleep Apnea-hypopnea Syndrome and Type 2 Diabetes
文献类型：期刊论文
| 作者 | Guo LiXin1; Zhao Xin2; Pan Qi1; Sun Xue1; Li Hui1; Wang XiaoXia1; Zhang LiNa1; Wang Yao1 |
| 刊名 | Chinese Medical Journal
 |
| 出版日期 | 2015 |
| 卷号 | 128期号:17页码:2301-2306 |
| 关键词 | Continuous Glucose Monitoring System Medicine R Continuous Positive Airway Pressure Obstructive Sleep Apnea-hypopnea Syndrome Type 2 Diabetes Mellitus |
| ISSN号 | 0366-6999 |
| 其他题名 | Effect of Continuous Positive Airway Pressure Therapy on Glycemic Excursions and Insulin Sensitivity in Patients with Obstructive Sleep Apnea-hypopnea Syndrome and Type 2 Diabetes |
| 英文摘要 | Background: For patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and type 2 diabetes mellitus (T2DM), the night sleep interruption and intermittent hypoxia due to apnea or hypopnea may induce glycemic excursions and reduce insulin sensitivity. This study aimed to investigate the effect of continuous positive airway pressure (CPAP) therapy in patients with OSAHS and T2DM. Methods: Continuous glucose monitoring system (CGMS) was used in 40 patients with T2DM and newly diagnosed OSAHS. The measurements were repeated after 30 days of CPAP treatment. Subsequently, insulin sensitivity and glycohemoglobin (HbA1c) were measured and compared to the pretreatment data. Results: After CPAP therapy, the CGMS indicators showed that the 24-h mean blood glucose (MBG) and the night time MBG were significantly reduced (P 7.8 mmol/L and > 11.1 mmol/L) decreased (P < 0.05 and P < 0.05, respectively) after the treatment. In addition, HbA1c levels were also lower than those before treatment (P < 0.05), and the homeostasis model assessment index of insulin resistance was also significantly lower than before CPAP treatment (P = 0.034). Conclusions: CPAP therapy may have a beneficial effect on improving not only blood glucose but also upon insulin sensitivity in T2DM patients with OSAHS. This suggests that CPAP may be an effective treatment for T2DM in addition to intensive diabetes management. |
| 资助项目 | [Foundation of Beijing Municipal Science and Technology Commission] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5507002 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/152104]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.Beijing Hosp, Department Endocrinol, Beijing 100730, Peoples R China 2.中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Guo LiXin,Zhao Xin,Pan Qi,et al. Effect of Continuous Positive Airway Pressure Therapy on Glycemic Excursions and Insulin Sensitivity in Patients with Obstructive Sleep Apnea-hypopnea Syndrome and Type 2 Diabetes[J]. Chinese Medical Journal,2015,128(17):2301-2306. |
| APA | Guo LiXin.,Zhao Xin.,Pan Qi.,Sun Xue.,Li Hui.,...&Wang Yao.(2015).Effect of Continuous Positive Airway Pressure Therapy on Glycemic Excursions and Insulin Sensitivity in Patients with Obstructive Sleep Apnea-hypopnea Syndrome and Type 2 Diabetes.Chinese Medical Journal,128(17),2301-2306. |
| MLA | Guo LiXin,et al."Effect of Continuous Positive Airway Pressure Therapy on Glycemic Excursions and Insulin Sensitivity in Patients with Obstructive Sleep Apnea-hypopnea Syndrome and Type 2 Diabetes".Chinese Medical Journal 128.17(2015):2301-2306. |
入库方式： OAI收割
来源：金属研究所
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