Design, Synthesis and Antitumor Activity of Pyrrolopyrazinone-chalcone Hybrids
文献类型：期刊论文
| 作者 | Meng Ying1; Zhang Hongwei1; Liu Zehua1; Zeng Shanchao1; Zhang Hongwei1; Sun Chiyu1; Zhang Lijuan1; Zhao Mingming1; Wang Guan2; Jiang Mengying2 |
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2014 |
| 卷号 | 30期号:4页码:624-631 |
| 关键词 | DERIVATIVES CELL HYDROXYCHALCONES AGENTS Pyrrolopyrazinone-chalcone hybrid Antitumor Marine sponge Combination principle |
| ISSN号 | 1005-9040 |
| 其他题名 | Design, Synthesis and Antitumor Activity of Pyrrolopyrazinone-chalcone Hybrids |
| 英文摘要 | A series of pyrrolopyrazinone-chalcone hybrids(12a-12q) was designed, synthesized and screened for their antitumor activity against SKOV-3, A549 and HeLa cell lines in vitro. Compared with the pyrrolopyrazinone(10a) and 5-fluorouracil(5-FU), nearly all the tested compounds showed significantly-improved antitumor activities. The most promising compounds 12e and 12k(IC50=0.25 and 0.88 mu mol/L) respectively show activities of 123 and 35 times that of compound 10a(IC50=30.74 mu mol/L) against HeLa cell line. The result reveals that the presence of chalcone moiety is beneficial to their activity and selectivity. |
| 资助项目 | [Program for Liaoning Innovative Research Team in University, China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5214900 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/152293]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国科学院金属研究所 2.吉林大学 |
| 推荐引用方式 GB/T 7714 | Meng Ying,Zhang Hongwei,Liu Zehua,et al. Design, Synthesis and Antitumor Activity of Pyrrolopyrazinone-chalcone Hybrids[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2014,30(4):624-631. |
| APA | Meng Ying.,Zhang Hongwei.,Liu Zehua.,Zeng Shanchao.,Zhang Hongwei.,...&Song Hongrui.(2014).Design, Synthesis and Antitumor Activity of Pyrrolopyrazinone-chalcone Hybrids.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,30(4),624-631. |
| MLA | Meng Ying,et al."Design, Synthesis and Antitumor Activity of Pyrrolopyrazinone-chalcone Hybrids".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 30.4(2014):624-631. |
入库方式： OAI收割
来源：金属研究所
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